| Vogt-koyanagi-harada syndrome. | |
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MedLine Citation:
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PMID: 18600484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Vogt-Koyanagi-Harada syndrome is a bilateral, chronic, diffuse granulomatous panuveitis frequently associated with neurological, auditory, and integumentary manifestations. It is also one of the most common forms of uveitis among pigmented races including Chinese patients. METHODS: This article reviews the current developments of Vogt-Koyanagi-Harada syndrome, including epidemiology, etiology, clinical features, observational techniques, genetics, treatment, and prognosis. RESULTS: Increasing reports have been published to describe the clinical features of Vogt-Koyanagi-Harada syndrome in various ethnic populations from different parts of the world. In spite of tremendous progress in laboratory and clinical research, the etiology of Vogt-Koyanagi-Harada syndrome is still not completely known. Numerous studies indicate an autoimmune nature for this disease. A recent study has shown that Th17, a new subset of T cell, plays an important role in the initiation and maintenance of this disease. Early and aggressive systemic corticosteroids are still the mainstay of initial therapy for Vogt-Koyanagi-Harada syndrome. However, nonsteroid immunomodulatory therapy, including cyclosporine, chlorambucil, cyclophosphamide, and azathioprine have brought out encouraging results. Improved visual outcomes in patients with Vogt-Koyanagi-Harada syndrome in recent years have been reported when compared with decades ago, presumably due to the more aggressive use of immunosuppressive agents. CONCLUSION: Although the prognosis for VKH syndrome was greatly improved, future prospective, controlled, multi-center studies are needed to determine the optimal treatment regime for this disease. The IL17/23 pathway may provide a novel therapeutic target to control inflammation in VKH syndrome. |
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Authors:
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Wang Fang; Peizeng Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current eye research Volume: 33 ISSN: 1460-2202 ISO Abbreviation: Curr. Eye Res. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2008-09-02 Revised Date: 2008-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 517-23 Citation Subset: IM |
Affiliation:
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The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China. peizengy@126.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Uveomeningoencephalitic Syndrome* / diagnosis, epidemiology, etiology, therapy |
| Comments/Corrections | |
Erratum In:
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Curr Eye Res. 2008 Sep;33(9):812. |
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