| Vogt-Koyanagi-Harada Disease, Diabetes Mellitus, and Psoriasis in a Child. | |
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MedLine Citation:
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PMID: 22188226 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: To report a case of a child with near-simultaneous onset of Vogt Koyanagi Harada disease (VKH) and insulin-dependent diabetes mellitus (IDDM). Design: Interventional case report. Methods: An 11-year-old child with known psoriasis presented with headache and bilateral granulomatous panuveitis. Nine weeks later, he presented with diabetic ketoacidosis and IDDM. Diffuse choroidal depigmentation followed within months. HLA was positive for DRB1*0405. Despite aggressive local and systemic therapy, the ocular disease was complicated by bilateral cataracts, angle closure glaucoma, and choroidal neovascularization. Results: The patient is currently pseudophakic in one eye and aphakic in the other, with best-corrected visual acuity of 6/24 and 6/5, respectively. Conclusions: VKH may present in children with panuveitis in the setting of other autoimmune disorders. Treating such patients is complicated by the need to minimize systemic corticosteroid use. A combination of local therapy and systemic steroid-sparing agents should be the mainstay of treatment. |
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Authors:
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Elvis Ojaimi; Jaime Levy; Richard Stawell; Anton Van Heerden; Tim Godfrey; Ehud Zamir |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-21 |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: - ISSN: 1744-5078 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The Ocular Immunology Clinic, Royal Victorian Eye and Ear Hospital , Melbourne , Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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