Document Detail


Vocal nodules and edema may be due to vibration-induced rises in capillary pressure.
MedLine Citation:
PMID:  18300711     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HYPOTHESIS: Vocal fold vibration may physically raise intravascular pressure to levels high enough to damage capillaries and result in leakage of erythrocytes. This type of injury is commonly seen in benign vocal fold lesions and is not well explained. STUDY DESIGN: Theoretical, retrospective. METHODS: The relationship of intravascular pressure to vibration frequency and amplitude is derived and confirmed with a physical blood vessel model, then applied to published human measurements to estimate human intravascular pressures. RESULTS: Vocal fold intravascular pressure is predicted to have a quadratic dependence on both frequency and amplitude. During speaking, the pressure may rise to over 20 cmH2O, and may reach levels far higher for screaming and singing. Such pressure magnitudes are known to trigger inflammatory cascades and can lead to fluid leakage. They also have the potential for pharmacologic control with beta-agonists. CONCLUSIONS: Intravascular pressure likely rises significantly during vocal fold vibration and may lead to the type of injury seen in benign vocal fold lesions. The results support voice therapy aimed at reducing vibratory amplitude. More vibratory amplitude measurements need to be performed in a wider range of subjects before the full range of human vocal fold vascular pressures can be estimated.
Authors:
Lukasz Czerwonka; Jack J Jiang; Chao Tao
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Laryngoscope     Volume:  118     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  748-52     Citation Subset:  IM    
Affiliation:
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Biomechanics
Blood Pressure / physiology*
Capillaries / physiopathology
Capillary Fragility / physiology*
Female
Humans
Laryngeal Diseases / etiology*
Laryngeal Edema / etiology*
Laryngeal Mucosa / blood supply
Male
Models, Cardiovascular
Phonation / physiology
Pressure
Retrospective Studies
Stress, Mechanical
Vibration / adverse effects
Vocal Cords / blood supply*
Voice / physiology*
Grant Support
ID/Acronym/Agency:
1-R01DC006019/DC/NIDCD NIH HHS; 1-R01DC05522/DC/NIDCD NIH HHS; 1-R01DC05522-07/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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