Document Detail

Vocal fold proteoglycans and their influence on biomechanics.
MedLine Citation:
PMID:  10369269     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE/HYPOTHESIS: To examine the interstitial proteins of the vocal fold and their influence on the biomechanical properties of that tissue. STUDY DESIGN: Anatomic study of the lamina propria of human cadaveric vocal folds combined with some viscosity testing. METHODS: Identification of proteoglycans is performed with histochemical staining. Quantitative analysis is performed using an image analysis system. A rheometer is used for viscosity testing. Three-dimensional rendering program is used for the computer images. RESULTS: Proteoglycans play an important role in tissue biomechanics. Hyaluronic acid is a key molecule that affects viscosity. DISCUSSION: The proteoglycans of the lamina propria have important biological and biomechanical effects. The role of hyaluronic acid in determining tissue viscosity is emphasized. Viscosity, its effect on phonatory threshold pressure and energy expended due to phonation is discussed. CONCLUSION: Proteoglycans, particularly hyaluronic acid, play important roles in determining biomechanical properties of tissue oscillation. Future research will likely make these proteins of important therapeutic interest.
S D Gray; I R Titze; R Chan; T H Hammond
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Laryngoscope     Volume:  109     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  845-54     Citation Subset:  IM    
National Center for Voice and Speech, Department of Surgery, University of Utah School of Medicine, Salt Lake City 84113, USA.
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MeSH Terms
Fibronectins / analysis
Hyaluronic Acid / analysis
Middle Aged
Phonation / physiology
Proteoglycans / analysis*,  metabolism
Sex Characteristics
Vocal Cords / chemistry*,  physiology
Grant Support
Reg. No./Substance:
0/Fibronectins; 0/Proteoglycans; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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