Document Detail


Vocal exercise may attenuate acute vocal fold inflammation.
MedLine Citation:
PMID:  23177745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES/HYPOTHESES: The objective was to assess the utility of selected "resonant voice" (RV) exercises for the reduction of acute vocal fold inflammation. The hypothesis was that relatively large-amplitude, low-impact vocal fold exercises associated with RV would reduce inflammation more than spontaneous speech (SS) and possibly more than voice rest.
STUDY DESIGN: The study design was prospective, randomized, and double blind.
METHODS: Nine vocally healthy adults underwent a 1-hour vocal loading procedure, followed by randomization to a SS condition, vocal rest condition, or RV exercise condition. Treatments were monitored in clinic for 4 hours and continued extraclinically until the next morning. At baseline (BL), immediately after loading, after the 4-hour in-clinic treatment, and 24 hours post-BL, secretions were suctioned from the vocal folds bilaterally and submitted to enzyme-linked immunosorbent assay to estimate concentrations of key markers of tissue injury and inflammation: interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor α, matrix metalloproteinase (MMP)-8, and IL-10.
RESULTS: Complete data sets were obtained for three markers--IL-1β, IL-6, and MMP-8--for one subject in each treatment condition. For these markers, results were poorest at 24-hour follow-up in the SS condition, sharply improved in the voice rest condition, and was the best in the RV condition. Average results for all markers and responsive subjects with normal BL mediator concentrations revealed an almost identical pattern.
CONCLUSIONS: Some forms of tissue mobilization may be useful to attenuate acute vocal fold inflammation.
Authors:
Katherine Verdolini Abbott; Nicole Y K Li; Ryan C Branski; Clark A Rosen; Elizabeth Grillo; Kimberly Steinhauer; Patricia A Hebda
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of voice : official journal of the Voice Foundation     Volume:  26     ISSN:  1873-4588     ISO Abbreviation:  J Voice     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2013-05-13     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8712262     Medline TA:  J Voice     Country:  United States    
Other Details:
Languages:  eng     Pagination:  814.e1-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The Voice Foundation. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. kittie@csd.pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / metabolism
Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Female
Humans
Inflammation Mediators / metabolism
Laryngitis / metabolism,  pathology,  physiopathology,  therapy*
Laryngoscopy
Linear Models
Male
Middle Aged
Pennsylvania
Phonation*
Pressure
Prospective Studies
Rest
Speech Production Measurement
Stroboscopy
Time Factors
Treatment Outcome
Vibration
Video Recording
Vocal Cords / metabolism,  pathology,  physiopathology*
Voice Quality*
Voice Training*
Young Adult
Grant Support
ID/Acronym/Agency:
R01 DC008290/DC/NIDCD NIH HHS; R01 DC5643/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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