Document Detail

Vocal handicap and quality of life after treatment of advanced squamous carcinoma of the larynx and/or hypopharynx.
MedLine Citation:
PMID:  21724367     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE/HYPOTHESIS: To evaluate and correlate voice-specific quality of life (QOL) and health-related QOL (HR-QOL) after treatment for advanced cancer of the larynx and/or hypopharynx.
STUDY DESIGN: Cross-sectional study.
METHODS: Patients submitted to partial laryngectomy (PL), salvage PL (sPL), concomitant radiotherapy and chemotherapy (RT+Chemo), total laryngectomy (TL), salvage TL (sTL), total pharyngolaryngectomy (TP) and salvage total pharyngolaryngectomy (sTP). The following questionnaires were used: (1) Voice Handicap Index (VHI) and (2) University of Washington Quality of Life Questionnaire (UW-QOL; version 4).
RESULTS: Eighty-four patients participated in the study. All the patients PL (10), sPL (1), and RT+Chemo (24) communicated by laryngeal voice. Of the 49 patients submitted to total removal of the larynx, 30 communicated with alaryngeal phonation, the major part being tracheoesophageal prosthesis (17). The worst subscale of VHI for the total patient group was functional (mean=13.15), and the value of the total score was 31. Patients submitted to PL, RT+Chemo, and TL presented slight handicap (medians of 27, 14, and 21.5, respectively). Patients treated with sTL, TP, and sTP presented moderate handicap (medians of 45, 37.5, and 31.5, respectively). HR-QOL was considered between good and excellent for 78.6% of the patients, and poor for 21.4%. The correlation between voice-specific QOL and HR-QOL was significant (P=0.0001).
CONCLUSION: Patients treated for advanced cancer of the larynx/hypopharynx present slight to moderate voice handicap and good/excellent HR-QOL. Stricter analysis of both the VHI and UW-QOL data suggests that more attention be given to the vocal handicap of the individual patient.
Elma Heitmann Mares Azevedo; Neyller Montoni; João Gonçalves Filho; Luiz Paulo Kowalski; Elisabete Carrara-de Angelis
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Publication Detail:
Type:  Journal Article     Date:  2011-07-02
Journal Detail:
Title:  Journal of voice : official journal of the Voice Foundation     Volume:  26     ISSN:  1873-4588     ISO Abbreviation:  J Voice     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-07-10     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  8712262     Medline TA:  J Voice     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e63-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The Voice Foundation. Published by Mosby, Inc. All rights reserved.
Department of Voice, Speech and Swallowing Rehabilitation, Hospital A. C. Camargo, São Paulo, Brazil.
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MeSH Terms
Aged, 80 and over
Brazil / epidemiology
Carcinoma, Squamous Cell / therapy*
Cross-Sectional Studies
Hypopharyngeal Neoplasms / therapy*
Laryngeal Neoplasms / therapy*
Middle Aged
Postoperative Complications / epidemiology*
Quality of Life
Voice Disorders / epidemiology*

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