Document Detail

Vivax malaria: a major cause of morbidity in early infancy.
MedLine Citation:
PMID:  19438395     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In areas where malaria is endemic, infants aged <3 months appear to be relatively protected from symptomatic and severe Plasmodium falciparum malaria, but less is known about the effect of Plasmodium vivax infection in this age group. METHODS: To define malaria morbidity in the first year of life in an area where both multidrug-resistant P. falciparum and P. vivax are highly prevalent, data were gathered on all infants attending a referral hospital in Papua, Indonesia, using systematic data forms and hospital computerized records. Additional clinical and laboratory data were prospectively collected from inpatients aged <3 months. RESULTS: From April 2004 through April 2008, 4976 infants were admitted to the hospital, of whom 1560 (31%) had malaria, with infection equally attributable to P. falciparum and P. vivax. The case-fatality rate was similar for inpatients with P. falciparum malaria (13 [2.2%] of 599 inpatients died) and P. vivax malaria (6 [1.0%] of 603 died; P= .161), whereas severe malarial anemia was more prevalent among those with P. vivax malaria (193 [32%] of 605 vs. 144 [24%] of 601; P= .025). Of the 187 infants aged <3 months, 102 (56%) had P. vivax malaria, and 55 (30%) had P. falciparum malaria. In these young infants, infection with P. vivax was associated with a greater risk of severe anemia (odds ratio, 2.4; 95% confidence interval, 1.03-5.91; P= .041) and severe thrombocytopenia (odds ratio, 3.3; 95% confidence interval, 1.07-10.6; P= .036) compared with those who have P. falciparum infection. CONCLUSIONS: P. vivax malaria is a major cause of morbidity in early infancy. Preventive strategies, early diagnosis, and prompt treatment should be initiated in the perinatal period.
Jeanne R Poespoprodjo; Wendelina Fobia; Enny Kenangalem; Daniel A Lampah; Afdal Hasanuddin; Noah Warikar; Paulus Sugiarto; Emiliana Tjitra; Nick M Anstey; Ric N Price
Related Documents :
6711505 - Infections in hypothermic infants younger than 3 months old.
19820425 - Detection of cytomegalovirus dna in dried blood spots of minnesota infants who do not p...
24793735 - Infant's visual preferences for facial traits associated with adult attractiveness judg...
17669105 - Helicobacter pylori colonization in the first 3 years of life in japanese children.
1052745 - Sex ratio of live births in south-western nigeria.
6532635 - Follow-up study of survivors of fetal and early onset neonatal listeriosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  48     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-28     Completed Date:  2009-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1704-12     Citation Subset:  IM    
District Health Authority, Menzies School of Health Research, National Institute of Health Research and Development Malaria Research Program, Jakarta, Indonesia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anemia / etiology
Endemic Diseases*
Indonesia / epidemiology
Infant, Newborn
Malaria, Falciparum / complications,  epidemiology
Malaria, Vivax / complications,  epidemiology*
Prospective Studies
Thrombocytopenia / etiology
Grant Support
074637//Wellcome Trust; GR071614MA//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nephrotoxicity associated with intravenous colistin (colistimethate sodium) treatment at a tertiary ...
Next Document:  A randomized trial comparing plasma drug concentrations and efficacies between 2 nonnucleoside rever...