| Vitrification of oocytes produces high pregnancy rates when carried out in fertile women. | |
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MedLine Citation:
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PMID: 19217099 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the efficiency of our vitrification technique when applied in young fertile women. DESIGN: Clinical research and application. SETTING: In vitro fertilization center. PATIENT(S): Twenty-one women were recruited from the navy community with 19 patients finishing the study. INTERVENTION(S): Vitrified oocytes with use of the electron microscopic grid method were warmed 6 months after vitrification. Surviving metaphase II oocytes were microinjected for fertilization, and clinical results were evaluated. MAIN OUTCOME MEASURE(S): Survival, fertilization, and cleavage rate. Pregnancy and implantation rate. RESULT(S): Three hundred ninety-five oocytes were warmed, of which 320 oocytes (81.0%) survived. Two hundred eighty-five metaphase II oocytes were microinjected for fertilization; 206 of them (72.3%) fertilized, and 53 embryos were transferred to 19 patients (in 20 warming cycles). Twenty-four of 53 transferred embryos (45.3%) implanted as confirmed by ultrasound examination. Of the 20 transfers, 16 resulted in clinical pregnancy (80%), 3 miscarried (15%), and 13 (65%) went on to produce 20 live births, respectively. This is much higher in comparison with our previous data using supernumerary oocytes where the rates of implantation and pregnancy were 6% and 21%. Live-birth rates per warmed oocyte and per injected oocyte were 5.1% and 7.2%, respectively. CONCLUSION(S): High pregnancy and implantation rates were observed after 6 months of cryopreservation by vitrification when oocytes from fertile woman were used. Proper screening of candidates for oocyte cryopreservation is of crucial importance to assure a favorable pregnancy outcome. |
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Authors:
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Thomas J Kim; Larry R Laufer; Seung Wook Hong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-12 |
Journal Detail:
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Title: Fertility and sterility Volume: 93 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 467-74 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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