Document Detail


Vitreous substitute. Experimental studies and review.
MedLine Citation:
PMID:  6729266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied a synthetic hydrogel, PHEA [poly(2-hydroxyethyl acrylate)], experimentally. The material is transparent, autoclavable , highly viscous, nonabsorbable, easily injectable, cohesive, and does not fragment on passage through small-gauge needles. Results in animal studies revealed that injection of PHEA into the vitreous cavity promoted inflammatory changes such as vitreous haziness , membrane formation, and chorioretinal atrophy. Histopathologic studies showed extensive retinal disorganization, chorioretinal scarring, and vitritis . We reviewed the literature and concluded that an ideal vitreous substitute for long-term use in complex cases of retinal detachment is not available at this time.
Authors:
I M Chan; F I Tolentino; M F Refojo; G Fournier; D M Albert
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  4     ISSN:  0275-004X     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:    1984 Winter-Spring
Date Detail:
Created Date:  1984-07-23     Completed Date:  1984-07-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Gels
Injections
Polyhydroxyethyl Methacrylate / administration & dosage,  analogs & derivatives,  therapeutic use*
Polymethacrylic Acids / therapeutic use*
Rabbits
Retina / drug effects
Viscosity
Vitreous Body / surgery*
Grant Support
ID/Acronym/Agency:
EY-00327/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Gels; 0/Polymethacrylic Acids; 25249-16-5/Polyhydroxyethyl Methacrylate; 26022-14-0/poly(2-hydroxyethyl acrylate)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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