| Vitreous alcohol is of limited value in predicting blood alcohol. | |
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MedLine Citation:
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PMID: 8206459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitreous humour alcohol concentration (VHAC) and blood alcohol concentration (BAC) measured by gas chromatography were available from 345 medico-legal autopsies. Simple linear regression with BAC as outcome variable and VHAC as predictor variable (range 1-705 mg%) gave the regression equation BAC = 3.03 + 0.852 VHAC with 95% prediction interval +/- 0.019 square root of [7157272 + (VHAC - 189.7)2] and 99% prediction interval +/- 0.025 square root of [7157272 + (VHAC - 189.7)2]. The residual standard deviation of VHAC was 26 mg%, the standard error of the slope 0.0098 and the 95% confidence interval for the slope 0.833-0.871. In practice a BAC of 80 mg% is predicted with 95% certainty by a VHAC of 150 mg% and similarly a BAC of 150 mg% by a VHAC of 232 mg%. The prediction interval is too wide to be of real practical use. Previous authors have provided various formulae, including a simple conversion factor, to predict BAC from VHAC without taking into account the uncertainty of the prediction for an individual subject. A re-analysis of the raw data from previous publications gave in most instances regression equations significantly different from the authors' own. |
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Authors:
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D J Pounder; N Kuroda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Forensic science international Volume: 65 ISSN: 0379-0738 ISO Abbreviation: Forensic Sci. Int. Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-07-11 Completed Date: 1994-07-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: IRELAND |
Other Details:
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Languages: eng Pagination: 73-80 Citation Subset: IM |
Affiliation:
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Department of Forensic Medicine, University of Dundee, Scotland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholic Intoxication
/
blood,
diagnosis Autopsy Chromatography, Gas Ethanol / analysis*, blood Forensic Medicine / methods* Humans Multiple Trauma / blood Overdose / blood Postmortem Changes Predictive Value of Tests Regression Analysis Retrospective Studies Suicide Vitreous Body / chemistry* |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
| Comments/Corrections | |
Comment In:
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Forensic Sci Int. 1995 May 22;73(2):157-8; author reply 159-60
[PMID:
7797190
]
Forensic Sci Int. 1995 May 22;73(2):155; author reply 159-60 [PMID: 7797189 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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