Document Detail

Vitreous SiO2-CaO coatings on Ti6Al4V alloys: reactivity in simulated body fluid versus osteoblast cell culture.
MedLine Citation:
PMID:  16765884     Owner:  NLM     Status:  MEDLINE    
Vitreous coatings of the SiO(2)-CaO system have been prepared on Ti6Al4V substrates by the sol-gel method. The textural parameters (porosity and roughness) and thickness of the films obtained increase when the concentration of the precursor solutions is raised. In vitro studies of these coatings have been performed using two approaches: soaking in simulated body fluid, and by growing osteoblasts on these materials. The results of both studies show differences in terms of chemical reactivity. While in simulated body fluid the coatings were dissolved without forming a bioactive surface, when osteoblast-like cells grew on the coatings they were more stable. Furthermore, cell culture assays show biocompatible behavior of these coatings making them of potential interest for clinical applications. The effect of the textural parameters of the obtained coatings on the cell functions (attachment, spreading, proliferation and differentiation) has also been studied. The results show an increase in these cell parameters as the roughness and porosity of the coatings increase.
I Izquierdo-Barba; F Conde; N Olmo; M A Lizarbe; M A García; M Vallet-Regí
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-27
Journal Detail:
Title:  Acta biomaterialia     Volume:  2     ISSN:  1742-7061     ISO Abbreviation:  -     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  England    
Other Details:
Languages:  eng     Pagination:  445-55     Citation Subset:  IM    
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
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MeSH Terms
Alkaline Phosphatase / analysis,  metabolism
Biological Markers / metabolism
Body Fluids / chemistry*
Calcium Compounds / chemistry*
Cell Adhesion
Cell Culture Techniques
Cell Differentiation
Cell Line
Cell Proliferation
Coated Materials, Biocompatible / chemical synthesis,  chemistry*
Computer Simulation*
Glass / chemistry*
Osteoblasts / cytology,  enzymology,  metabolism*,  physiology,  ultrastructure
Oxides / chemistry*
Titanium / chemistry*
X-Ray Diffraction
Reg. No./Substance:
0/Biological Markers; 0/Calcium Compounds; 0/Coated Materials, Biocompatible; 0/Oxides; 12743-70-3/titanium alloy (TiAl6V4); 1305-78-8/lime; 7440-32-6/Titanium; EC Phosphatase

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