Document Detail


Vitiligo at Injection Site of PEG-IFN-α 2a in Two Patients with Chronic Hepatitis C: Case Report and Literature Review.
MedLine Citation:
PMID:  21076689     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A 72-year-old female and a 57-year-old male with chronic hepatitis C were treated with a combination therapy of pegylated interferon (PEG-IFN)-α 2a (180 μg s.c. once a week) and ribavirin (1,000 mg orally daily). This resulted in the destruction of melanocytes at the injection site in both patients. In the male patient, the depigmentation progressed to the surrounding skin area. The dermatologist concurred with vitiligo as the diagnosis in both patients. Injection and surrounding site vitiligo associated with PEG-IFN-α 2b treatment for hepatitis C was noticed in previous case studies. For the first time, the case reports below highlight the same immunological adverse event secondary to PEG IFN-α 2a/ribavirin combination therapy and explain, in part, the complex interaction between host immune response and viral genotype. In addition, we systematically review drug-induced vitiligo and autoimmune diseases associated with the depigmentation disorder.
Authors:
V Arya; M Bansal; L Girard; S Arya; A Valluri
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-8-27
Journal Detail:
Title:  Case reports in dermatology     Volume:  2     ISSN:  1662-6567     ISO Abbreviation:  Case Rep Dermatol     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517685     Medline TA:  Case Rep Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  156-164     Citation Subset:  -    
Affiliation:
Wyckoff Heights Medical Center, Brooklyn, N.Y., USA.
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