Document Detail


Vitelliform dystrophy: long-term observations on New Zealand pedigrees.
MedLine Citation:
PMID:  1958368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term observations on 29 patients from four pedigrees with vitelliform dystrophy (Best's disease) are described. The majority of patients were examined at yearly intervals and had a mean follow-up of 7.4 years. For analysis, eyes were staged according to Mohler and Fine's classification. Although vitelliform dystrophy exhibited considerable polymorphism in the study group 'recognisable stages', such as egg-yolk cysts, scrambled cysts or pseudohypopyon, were present in 48% of eyes at the initial examination. Egg-yolk cysts and pseudohypopyons were found to be the most evanescent of stages lasting on average 2.0 and 2.4 years respectively. Evolution of lesions did not necessarily follow a regular progression through the later stages of the vitelliform classification. Several unusual features such as recurrent pseudohypopyon, apparent regeneration of retinal pigment epithelium, exudative retinal detachments and development of stellate pigment figures were observed during the study. The majority of patients retained 6/12 or better visual acuity until the fourth decade when vision deteriorated. Correlations between changes in visual acuity and staging of the fundal lesions were made. Similarities between the group of patients reported, and a comparative group from overseas' have been discussed.
Authors:
R Clemett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian and New Zealand journal of ophthalmology     Volume:  19     ISSN:  0814-9763     ISO Abbreviation:  Aust N Z J Ophthalmol     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-01-06     Completed Date:  1992-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8505423     Medline TA:  Aust N Z J Ophthalmol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
Affiliation:
Christchurch School of Medicine, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Cysts / etiology
Female
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Longitudinal Studies
Male
Middle Aged
Pedigree
Retinal Degeneration / genetics*,  pathology
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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