Document Detail

Vitamins, selenium, iron, and coronary heart disease risk in Indians, Malays, and Chinese in Singapore.
MedLine Citation:
PMID:  9616423     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To examine the hypothesis that the higher rates of coronary heart disease (CHD) in Indians (South Asians) compared with Malays and Chinese is partly because of differences in antioxidants (vitamins A, C, and E, and selenium) and pro-oxidants (iron). DESIGN: Cross sectional study of the general population. SETTING: Singapore. PARTICIPANTS: Random sample of 941 persons aged 30 to 69 years. MAIN RESULTS: There were moderate correlations between vitamin A and vitamin E, and between these vitamins and selenium. Mean plasma vitamins A and E were similar by ethnic group. Vitamin A concentration for Indians were (men 0.66 and women 0.51 mg/l), Malays (men 0.67 and women 0.54 mg/l), and Chinese (men 0.68 and women 0.52 mg/l). Vitamin E concentrations for Indians were (men 12.9 and women 12.8 mg/l), Malays (men 13.6 and women 13.3 mg/l), and Chinese (men 12.6 and women 12.6 mg/l). In contrast, mean plasma vitamin C concentrations were lower in Indians (men 5.7 and women 6.9 mg/l) and Malays (men 5.1 and women 6.4 mg/l) than Chinese (men 6.3 and women 8.4 mg/l). Mean serum selenium was lower in Indians (men 117 and women 115 micrograms/l) than Malays (men 122 and women 122 micrograms/l) and Chinese (men 126 and women 119 micrograms/l). Mean serum ferritin was much lower in Indians (men 132 and women 50 micrograms/l) than Malays (men 175 and women 85 micrograms/l) and Chinese (men 236 and women 92 micrograms/l). MAIN CONCLUSIONS: Lower vitamin C and selenium in Indians, particularly in combination, could play a part in their increased risk of CHD. Vitamins A and E, and ferritin (iron) have no such role. Lower vitamin C in Indians and Malays is probably because of its destruction by more prolonged cooking. In Indians, lower selenium is probably because of a lower dietary intake and the much lower ferritin to a lower dietary intake of iron and its binding by phytates.
K Hughes; C N Ong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of epidemiology and community health     Volume:  52     ISSN:  0143-005X     ISO Abbreviation:  J Epidemiol Community Health     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-06-25     Completed Date:  1998-06-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7909766     Medline TA:  J Epidemiol Community Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
Department of Community, Occupational, and Family Medicine, National University of Singapore, Faculty of Medicine, Singapore.
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MeSH Terms
Ascorbic Acid / blood*
China / ethnology
Coronary Disease / ethnology,  etiology*
Cross-Sectional Studies
Ferritins / blood*
India / ethnology
Malaysia / ethnology
Middle Aged
Risk Factors
Selenium / blood*
Singapore / epidemiology
Vitamin A / blood
Vitamin E / blood*
Reg. No./Substance:
11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 7782-49-2/Selenium; 9007-73-2/Ferritins
Comment In:
J Epidemiol Community Health. 1998 Nov;52(11):764   [PMID:  10396513 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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