Document Detail

Vitamins, folic acid and neural tube defects: comments on investigations in the United States.
MedLine Citation:
PMID:  1766937     Owner:  NLM     Status:  MEDLINE    
No clear answer concerning whether multivitamin/folate supplementation prevents neural tube defects (NTDs) is provided by three studies in the United States. All these studies are occurrence in nature, no recurrence studies having been conducted. The Atlanta Birth Defects Study is subject to pronounced memory and recall biases, the length between event and interview being as long as 16 years. In a second study (Boston University), objections can be raised to certain aspects of the experimental design, and the claim that 22 per cent of women started vitamins sufficiently early after pregnancy diagnosis to influence NTD formation is suspicious. Our NICHD case control study of 541 women in California and Illinois revealed no evidence for multivitamins or folic acid preventing NTDs. U.S. public policy-makers face difficulties in applying results of recurrence or occurrence studies in high-risk areas to low-risk areas in the U.S.
J L Simpson; J L Mills; G G Rhoads; G C Cunningham; H J Hoffman; M R Conley
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  11     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-02-20     Completed Date:  1992-02-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  641-8     Citation Subset:  IM    
University of Tennessee, Memphis.
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MeSH Terms
Folic Acid / therapeutic use*
Neural Tube Defects / epidemiology*,  prevention & control
Odds Ratio
Pregnancy Trimester, First
Research Design
United States
Vitamins / therapeutic use*
Reg. No./Substance:
0/Vitamins; 59-30-3/Folic Acid
Comment In:
Prenat Diagn. 1992 Oct;12(10):856-9   [PMID:  1475260 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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