| Vitamins A, E, microelements and membrane lipid peroxidation in patients with neoplastic disease treated with calcium antagonists and antagonists of receptors H2. | |
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MedLine Citation:
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PMID: 15274309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the serum levels of vitamins A, E, zinc and copper in two hundred and twenty-five subjects of both sexes. They were divided into two groups: 87 healthy subjects who served as controls and 138 patients with neoplastic disease. The patients were subdivided according to the absence (n = 79) or the presence of metastatic disease (n =59). In 59 patients with cancer, who were in therapy with scavenger drugs of free radical such as calcium antagonists and the antagonists of receptors H2, we also studied the possible effect of the same therapy on the serum levels of vitamins, on the concentrations of the microelements and on membrane lipid peroxidation. We found that membrane lipid peroxidation, evaluated from the time of in vitro formation in the blood of so-called "Heinz bodies," decreased in all patients treated with scavenger drugs. In these patients the permeability of the erythrocyte membrane was similar to the controls and the serum levels of the vitamins were equal to the levels in patients who did not receive these therapies. Zinc concentration increased while copper remained unchanged. We also studied the levels of vitamins in some organs. The results are discussed considering the role of free radicals. We underline the importance of vitamins A and E in the protection from membranous peroxidation and from free radicals and the need to consider cancer as a systemic morbid event, apart from the contingent actual location. |
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Authors:
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Filippo della Rovere; Angelo Granata; Rosaria Pavia; Antonio Tomaino; Agata Zirilli; Francesco Monaco; Dario Familiari; Annunziata La Rocca; Riccardo Ientile; Baldassare Mondello; Giacomo Basile; Maurizio Monaco |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 24 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2004 May-Jun |
Date Detail:
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Created Date: 2004-07-27 Completed Date: 2004-09-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 1449-53 Citation Subset: IM |
Affiliation:
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U.O.C. Thoracic Surgery, Facoltà di Farmacia, University of Messina, Messina, Italy. fdellarovere@unime.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Calcium Channel Blockers / pharmacology* Case-Control Studies Cell Membrane Permeability / drug effects Copper / blood* Erythrocyte Membrane / drug effects, metabolism Female Free Radical Scavengers / pharmacology Histamine H2 Antagonists / pharmacology* Humans Lipid Peroxidation / drug effects Male Middle Aged Neoplasms / blood*, drug therapy* Prospective Studies Vitamin A / blood* Vitamin E / blood* Zinc / blood* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Free Radical Scavengers; 0/Histamine H2 Antagonists; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 7440-50-8/Copper; 7440-66-6/Zinc |
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