| Vitamin A supplementation increases ratios of proinflammatory to anti-inflammatory cytokine responses in pregnancy and lactation. | |
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MedLine Citation:
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PMID: 16734607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin A supplementation reduces child mortality in populations at risk of vitamin A deficiency and may also reduce maternal mortality. One possible explanation for this is that vitamin A deficiency is associated with altered immune function and cytokine dysregulation. Vitamin A deficiency in pregnancy may thus compound the pregnancy-associated bias of cellular immune responses towards Th-2-like responses and exacerbate susceptibility to intracellular pathogens. We assessed mitogen and antigen-induced cytokine responses during pregnancy and lactation in Ghanaian primigravidae receiving either vitamin A supplementation or placebo. This was a double-blind, randomized, placebo-controlled trial of weekly vitamin A supplementation in pregnant and lactating women. Pregnancy compared to postpartum was associated with a suppression of cytokine responses, in particular of the proinflammatory cytokines interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha. Mitogen-induced TNF-alpha responses were associated with a decreased risk of peripheral parasitaemia during pregnancy. Furthermore, vitamin A supplementation was significantly associated with an increased ratio of mitogen-induced proinflammatory cytokine (IFN-gamma) to anti-inflammatory cytokine (IL-10) during pregnancy and in the postpartum period. The results of this study indicate that suppression of proinflammatory type 1 immune responses and hence immunity to intracellular infections, resulting from the combined effects of pregnancy and vitamin A deficiency, might be ameliorated by vitamin A supplementation. |
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Authors:
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S E Cox; P Arthur; B R Kirkwood; K Yeboah-Antwi; E M Riley |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 144 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-31 Completed Date: 2006-06-29 Revised Date: 2013-06-07 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 392-400 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK. sharon.cox@lshtm.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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biosynthesis* Double-Blind Method Female Humans Immunity, Cellular / drug effects Interferon-gamma / biosynthesis Interleukin-10 / biosynthesis Lactation / immunology* Parasitemia / immunology Phytohemagglutinins / immunology Postnatal Care / methods Pregnancy Pregnancy Complications / immunology* Pregnancy Complications, Parasitic / immunology, prevention & control Prenatal Care / methods Tuberculin / immunology Tumor Necrosis Factor-alpha / biosynthesis Vitamin A / blood, immunology*, therapeutic use Vitamin A Deficiency / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Phytohemagglutinins; 0/Tuberculin; 0/Tumor Necrosis Factor-alpha; 11103-57-4/Vitamin A; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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