Document Detail

Vitamin A supplementation increases ratios of proinflammatory to anti-inflammatory cytokine responses in pregnancy and lactation.
MedLine Citation:
PMID:  16734607     Owner:  NLM     Status:  MEDLINE    
Vitamin A supplementation reduces child mortality in populations at risk of vitamin A deficiency and may also reduce maternal mortality. One possible explanation for this is that vitamin A deficiency is associated with altered immune function and cytokine dysregulation. Vitamin A deficiency in pregnancy may thus compound the pregnancy-associated bias of cellular immune responses towards Th-2-like responses and exacerbate susceptibility to intracellular pathogens. We assessed mitogen and antigen-induced cytokine responses during pregnancy and lactation in Ghanaian primigravidae receiving either vitamin A supplementation or placebo. This was a double-blind, randomized, placebo-controlled trial of weekly vitamin A supplementation in pregnant and lactating women. Pregnancy compared to postpartum was associated with a suppression of cytokine responses, in particular of the proinflammatory cytokines interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha. Mitogen-induced TNF-alpha responses were associated with a decreased risk of peripheral parasitaemia during pregnancy. Furthermore, vitamin A supplementation was significantly associated with an increased ratio of mitogen-induced proinflammatory cytokine (IFN-gamma) to anti-inflammatory cytokine (IL-10) during pregnancy and in the postpartum period. The results of this study indicate that suppression of proinflammatory type 1 immune responses and hence immunity to intracellular infections, resulting from the combined effects of pregnancy and vitamin A deficiency, might be ameliorated by vitamin A supplementation.
S E Cox; P Arthur; B R Kirkwood; K Yeboah-Antwi; E M Riley
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  144     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-31     Completed Date:  2006-06-29     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  392-400     Citation Subset:  IM    
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK.
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MeSH Terms
Cytokines / biosynthesis*
Double-Blind Method
Immunity, Cellular / drug effects
Interferon-gamma / biosynthesis
Interleukin-10 / biosynthesis
Lactation / immunology*
Parasitemia / immunology
Phytohemagglutinins / immunology
Postnatal Care / methods
Pregnancy Complications / immunology*
Pregnancy Complications, Parasitic / immunology,  prevention & control
Prenatal Care / methods
Tuberculin / immunology
Tumor Necrosis Factor-alpha / biosynthesis
Vitamin A / blood,  immunology*,  therapeutic use
Vitamin A Deficiency / immunology*
Reg. No./Substance:
0/Cytokines; 0/Phytohemagglutinins; 0/Tuberculin; 0/Tumor Necrosis Factor-alpha; 11103-57-4/Vitamin A; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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