Document Detail

Vitamin A status of children in the urban slums of Karachi, Pakistan, assessed by clinical, dietary, and biochemical methods.
MedLine Citation:
PMID:  8427393     Owner:  NLM     Status:  MEDLINE    
We assessed the vitamin A status of 532 children with an age range of 6-60 months who were living in slum areas of Karachi, Pakistan, using three methodologies: clinical eye examination, dietary vitamin A intake, and serum retinol level. No definite clinical signs of xerophthalmia were observed in any of these children. The mean +/- SD vitamin A intake estimated from a food frequency questionnaire for the group with inadequate (low and deficient) serum retinol levels (< 20 micrograms/dl) was 362 +/- 332 retinol equivalents (RE) compared with 431 +/- 332) RE in the group with adequate serum levels (P < 0.005). Deficient serum retinol levels (< 10 micrograms/dl) were present in 12 children (2%); two of these had a healed corneal scar. Low serum retinol levels (10-19 micrograms/dl) were present in 46%, while 51% children had adequate levels (> or = 20 micrograms/dl). The mean +/- SD serum retinol level for the inadequate (< 20 micrograms/dl) and adequate groups were 15.3 +/- 2.8 and 26.6 +/- 6.7 micrograms/dl, respectively. These results suggest that a significant number of children in these communities have low vitamin A levels and thus may constitute an at risk group. These results also suggest that the dietary intake method may be a simple and inexpensive screening tool for assessment of vitamin A status in communities.
A Molla; S H Badruddin; M Khurshid; A M Molla; F N Rahaman; S Durrani; A Suria; J D Snyder; K Hendricks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  48     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-02     Completed Date:  1993-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  89-96     Citation Subset:  AIM; IM    
Department of Pathology, Aga Khan University Medical Centre, Karachi, Pakistan.
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MeSH Terms
Child, Preschool
Cluster Analysis
Diet Records
Nutritional Status
Pakistan / epidemiology
Prospective Studies
Retinol-Binding Proteins / analysis
Socioeconomic Factors
Urban Population
Vitamin A / administration & dosage,  blood*
Vitamin A Deficiency / epidemiology*
Xerophthalmia / epidemiology*
Reg. No./Substance:
0/Retinol-Binding Proteins; 11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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