| Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases. | |
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MedLine Citation:
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PMID: 17169566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alpha-synuclein (alphaS) is the major component of the filamentous inclusions that constitute defining characteristics of Lewy body diseases (LBD) and multiple system atrophy (MSA). Clinically, antioxidant vitamins, such as vitamin E and the vitamin-like substance coenzyme Q10, have been used in the treatment of LBD with some efficacy. Using fluorescence spectroscopy with thioflavin S, electron microscopy and atomic force microscopy, here we examined the effects of ten antioxidant vitamins and vitamin-like substances, vitamin A (retinol, retinal and retinoic acid), beta-carotene, vitamins B2, B6, C, E, coenzyme Q10 and alpha-lipoic acid, on the formation of alphaS fibrils (falphaS) and on preformed falphaS. Among them, vitamin A, beta-carotene and coenzyme Q10 dose-dependently inhibited the formation of falphaS. Moreover, they also dose-dependently destabilized preformed falphaS. With such potent anti-fibrillogenic as well as fibril-destabilizing activities, these compounds could be useful in the treatment and prevention of LBD and MSA. |
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Authors:
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Kenjiro Ono; Masahito Yamada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-12 |
Journal Detail:
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Title: Neurobiology of disease Volume: 25 ISSN: 0969-9961 ISO Abbreviation: Neurobiol. Dis. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-26 Completed Date: 2007-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9500169 Medline TA: Neurobiol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 446-54 Citation Subset: IM |
Affiliation:
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Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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chemistry,
pharmacology Coenzymes Humans Lewy Body Disease / metabolism* Microscopy, Atomic Force Microscopy, Electron Microscopy, Fluorescence Neurofibrils / drug effects*, metabolism, ultrastructure Neuroprotective Agents / chemistry*, pharmacology Parkinson Disease / metabolism* Thiazoles Ubiquinone / analogs & derivatives, chemistry, pharmacology Vitamin A / chemistry*, pharmacology Vitamins / chemistry, pharmacology alpha-Synuclein / chemistry, drug effects*, metabolism beta Carotene / chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Coenzymes; 0/Neuroprotective Agents; 0/Thiazoles; 0/Vitamins; 0/alpha-Synuclein; 11103-57-4/Vitamin A; 1339-63-5/Ubiquinone; 2390-54-7/thioflavin T; 303-98-0/coenzyme Q10; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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