Document Detail


Vitamin, mineral, and specialty supplements and risk of hematologic malignancies in the prospective VITamins And Lifestyle (VITAL) study.
MedLine Citation:
PMID:  21803844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Increasing evidence suggests that nutrients from fruits and vegetables have chemoprotective effects on various cancers including hematologic malignancies, but the effects of nutritional supplements are poorly examined.
METHODS: Herein, we prospectively evaluated the association of vitamin, mineral, and specialty supplements with incident hematologic malignancies in 66,227 men and women aged 50 to 76 years from Washington State recruited from year 2000 to 2002 to the VITamins And Lifestyle (VITAL) cohort study. Hematologic malignancies cases (n = 588) were identified through December 2008 by linkage to the Surveillance, Epidemiology, and End Results (SEER) cancer registry. HRs and 95% CIs associated with supplement use were estimated with Cox proportional hazards models.
RESULTS: After adjustment, high use of garlic supplements [≥4 days per week for ≥3 years; HR = 0.55 (95% CI = 0.34-0.87); P(trend) = 0.028] and ever use of grape seed supplements [HR = 0.57 (95% CI = 0.37-0.88)] were inversely associated with hematologic malignancies in our models. In addition, high use (8-10 pill-years) of multivitamins was suggestive of an inverse association [HR = 0.80 (95% CI = 0.64-1.01)]. In contrast, no associations were observed for the remaining supplements.
CONCLUSIONS: These data indicate that the use of garlic and grape seed may be associated with reduced risk of hematologic malignancies.
IMPACT: This is the first cohort study to suggest a possible role of these supplements in the chemoprevention of hematologic malignancies.
Authors:
Roland B Walter; Theodore M Brasky; Filippo Milano; Emily White
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-29
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  20     ISSN:  1538-7755     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-07     Completed Date:  2012-02-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2298-308     Citation Subset:  IM    
Copyright Information:
©2011 AACR
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MeSH Terms
Descriptor/Qualifier:
Aged
Cohort Studies
Dietary Supplements*
Female
Follow-Up Studies
Hematologic Neoplasms / prevention & control*
Humans
Life Style*
Male
Middle Aged
Minerals / therapeutic use*
Prognosis
Prospective Studies
Vitamins / therapeutic use*
Washington
Grant Support
ID/Acronym/Agency:
K05 CA154337/CA/NCI NIH HHS; K05-CA154337/CA/NCI NIH HHS; P30 CA015704-35S6/CA/NCI NIH HHS; P30-CA15704-35S6/CA/NCI NIH HHS; R01 CA142545/CA/NCI NIH HHS; R01 CA142545-03/CA/NCI NIH HHS; R01-CA142545/CA/NCI NIH HHS; R25 CA094880/CA/NCI NIH HHS; R25 CA094880-10/CA/NCI NIH HHS; R25-CA094880/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Minerals; 0/Vitamins
Comments/Corrections

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