Document Detail


Vitamin K deficiency is associated with incident knee osteoarthritis.
MedLine Citation:
PMID:  23410565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Osteoarthritis is the most common form of arthritis, with knee osteoarthritis being the leading cause of lower extremity disability among older adults in the US. There are no treatments available to prevent the structural pathology of osteoarthritis. Because of vitamin K's role in regulating skeletal mineralization, it has potential to be a preventative option for osteoarthritis. We therefore examined the relation of vitamin K to new-onset radiographic knee osteoarthritis and early osteoarthritis changes on magnetic resonance imaging (MRI).
METHODS: Subjects from the Multicenter Osteoarthritis (MOST) Study had knee radiographs and MRI scans obtained at baseline and 30 months later, and plasma phylloquinone (vitamin K) measured at baseline. We examined the relationship of subclinical vitamin K deficiency to incident radiographic knee osteoarthritis and MRI-based cartilage lesions and osteophytes, respectively, using log binomial regression with generalized estimating equations, adjusting for potential confounders.
RESULTS: Among 1180 participants (62% women, mean age 62±8 years, mean body mass index 30.1±5.1 kg/m(2)), subclinical vitamin K deficiency was associated with incident radiographic knee osteoarthritis (risk ratio [RR] 1.56; 95% confidence interval [CI], 1.08-2.25) and cartilage lesions (RR 2.39; 95% CI, 1.05-5.40) compared with no deficiency, but not with osteophytes (RR 2.35; 95% CI, 0.54-10.13). Subclinically vitamin K-deficient subjects were more likely to develop osteoarthritis in one or both knees than neither knee (RR 1.33; 95% CI, 1.01-1.75 and RR 2.12; 95% CI, 1.06-4.24, respectively).
CONCLUSION: In the first such longitudinal study, subclinical vitamin K deficiency was associated with increased risk of developing radiographic knee osteoarthritis and MRI-based cartilage lesions. Further study of vitamin K is warranted given its therapeutic/prophylactic potential for osteoarthritis.
Authors:
Devyani Misra; Sarah L Booth; Irina Tolstykh; David T Felson; Michael C Nevitt; Cora E Lewis; James Torner; Tuhina Neogi
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  126     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-04-11     Revised Date:  2013-12-03    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Humans
Knee Joint / pathology,  radiography
Longitudinal Studies
Male
Middle Aged
Osteoarthritis, Knee / epidemiology,  etiology*,  pathology,  radiography
Vitamin K / blood
Vitamin K Deficiency / complications*,  epidemiology
Grant Support
ID/Acronym/Agency:
AG14759/AG/NIA NIH HHS; AR47785/AR/NIAMS NIH HHS; HL696272/HL/NHLBI NIH HHS; K23 AR055127/AR/NIAMS NIH HHS; K23 AR055127/AR/NIAMS NIH HHS; P60 AR047785/AR/NIAMS NIH HHS; U01 AG018820/AG/NIA NIH HHS; U01 AG018832/AG/NIA NIH HHS; U01 AG018947/AG/NIA NIH HHS; U01 AG019069/AG/NIA NIH HHS; U01-AG18820/AG/NIA NIH HHS; U01-AG18832/AG/NIA NIH HHS; U01-AG18947/AG/NIA NIH HHS; U01-AG19069/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
12001-79-5/Vitamin K
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