Document Detail

Vitamin A in cystic fibrosis: case report and review of the literature.
MedLine Citation:
PMID:  2406407     Owner:  NLM     Status:  MEDLINE    
Much has been learned about vitamin A physiology in the last 50 years, yet few changes have been made in therapy. Unfamiliarity with vitamin A bioavailability and distribution may inadvertently result in toxicity. A literature search demonstrates that hypovitaminosis A has rarely been reported in patients with cystic fibrosis, and may manifest very differently in children of different ages. Furthermore, hypervitaminosis A may present with similar features, and can result from correction of deficiency. We report such a case in a 4.5-month-old infant, newly diagnosed with cystic fibrosis, who suffered first from vitamin A deficiency and then vitamin A toxicity. A brief review of vitamin A physiology, deficiency, and toxicity is presented.
N S Eid; L R Shoemaker; T D Samiec
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  10     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-29     Completed Date:  1990-03-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
Department of Pediatrics, University of Louisville School of Medicine, Kentucky.
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MeSH Terms
Biological Availability
Cystic Fibrosis / diagnosis*,  drug therapy,  metabolism
Hypervitaminosis A / diagnosis*,  drug therapy,  metabolism
Vitamin A / therapeutic use
Vitamin A Deficiency / diagnosis*,  drug therapy,  metabolism
Reg. No./Substance:
11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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