| Vitamin A improves insulin sensitivity by increasing insulin receptor phosphorylation through protein tyrosine phosphatase1B regulation at early age in obese rats of WNIN/Ob strain. | |
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MedLine Citation:
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PMID: 21466649 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To test the hypothesis that early intervention of vitamin A-enriched diet contains the development of obesity and improves insulin resistance, 50days old male lean and obese rats of WNIN/Ob strain were given either stock diet (2.6mg vitamin A/ kg diet) or vitamin A-enriched diet (129mg vitamin A/kg diet) for three months. Compared to stock diet-fed obese rats, vitamin A-enriched diet fed-obese rats had reduced body weight gain, visceral adiposity and improved insulin sensitivity as evidenced by decreased fasting plasma insulin and unaltered glucose levels, which could possibly be due to higher phosphorylation of soleus muscle insulin receptor. This in turn is explained by decreased protein tyrosine phosphatase1B (PTP1B) levels. Most of these changes were not observed in lean rats. In conclusion, chronic feeding of vitamin A-enriched diet to obese rats at an early age ameliorates visceral adiposity and improves the insulin sensitivity, possibly by decreasing soleus muscle PTP1B levels. |
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Authors:
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Shanmugam M Jeyakumar; Prathipati Vijaya Kumar; Nappan V Giridharan; Ayyalasomayajula Vajreswari |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Biochemistry, National Institute of Nutrition, Jamai-Osmania P O, Hyderabad-500 604, India. National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Jamai-Osmania P O, Hyderabad-500 604, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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