Document Detail


Vitamin A-enriched Diet Modulates Reverse Cholesterol Transport in Hypercholesterolemic Obese Rats of the WNIN/Ob Strain.
MedLine Citation:
PMID:  25100235     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim: Vitamin A plays a major role in lipid metabolism. Previously, we reported that chronic vitamin A feeding (129 mg/kg) for two months normalized the abnormally high plasma HDL-cholesterol (HDL-C) levels in hypercholesterolemic obese rats by upregulating the hepatic scavenger receptor class B type 1 (SR-BI) expression. In this report, we hypothesize that the administration of a dose less than 129 mg of vitamin A/kg would also be effective in lowering the plasma HDL-C levels in these rats. Methods: Changes in the activity and expression of proteins related to RCT were analyzed together with blood parameters in five-month-old male lean and obese rats supplemented with 2.6 (control group), 26, 52 and 129 mg of vitamin A/kg as retinyl palmitate for 20 weeks. Results: Vitamin A supplementation in the obese rats decreased the plasma HDL-C levels with a concomitant increase in the hepatic SR-BI expression and lipase activity compared to that observed in the control diet-fed obese rats treated with 2.6 mg of vitamin A/kg diet. Furthermore, vitamin A supplementation at doses of 52 and 129 mg/kg diet reduced the plasma lecithin cholesterol acyltransferase activity and increased the hepatic ATP-binding cassette transporter protein A1 expression in the obese rats. Interestingly, most of these changes were not observed in the lean rats fed a vitamin A-enriched diet. Conclusions: Chronic feeding of a vitamin A-enriched diet in hypercholesterolemic obese rats normalizes the plasma HDL-C level and presumably improves RCT, with an effective dose of 52 mg/kg diet. Further studies should focus on the pharmacological potential of vitamin A supplementation to correct an abnormal human obesity-associated lipoprotein metabolism.
Authors:
Anamthathmakula Prashanth; Shanmugam M Jeyakumar; Nappan V Giridharan; Ayyalasomayajula Vajreswari
Related Documents :
12770265 - Effect of 1-(4-phenoxyphenoxypropyl)imidazole (ks-175) on larval growth in the silkworm...
6149725 - Oral toxicity of bacillus thuringiensis subsp. israelensis to adult mosquitoes.
24102935 - Ultrasonographic characteristics of lipiduria in clinically normal cats.
2849625 - Role of midgut electrogenic k+ pump potential difference in regulating lumen k+ and ph ...
24827565 - Effects of medicated diet to eradicate helicobacter spp. on growth, pathology, and infe...
16134815 - Study of some immunity parameters in patients receiving low-caloric diets.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-06
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  -     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Different aspects of performance feedback engage different brain areas: Disentangling valence and ex...
Next Document:  Suppressive Effects of Standard-dose Rosuvastatin Therapy on the Progression of Coronary Atheroscler...