Document Detail


Vitamin A dynamics in breastmilk and liver stores: a life history perspective.
MedLine Citation:
PMID:  21695742     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Newborns are dependent on breastmilk vitamin A for building hepatic stores of vitamin A that will become critical for survival after weaning. It has been documented that vitamin A concentrations in breastmilk decline across the first year postpartum in both well-nourished and malnourished populations. The reason for this decline has been assumed to be a sign of concurrently depleting maternal hepatic stores. This study investigates this assumption to clarify why the decline occurs, drawing on life history theory.
METHODS: A cross sectional survey was conducted among lactating mothers in Kenya in 2006. Data were used to examine (1) the relationship between liver vitamin A and time, (2) if the relationship between milk and liver vitamin A varies by time, and (3) by maternal parity.
RESULTS: The relationship between liver vitamin A and time fits the quadratic pattern with marginal significance (P = 0.071, n = 192); the liver vitamin A declined during early postpartum then recovered in late postpartum time, controlling covariates. The milk-liver vitamin A relationship varied by postpartum time periods (P = 0.03) and by maternal parity (P = 0.005). Mothers in earlier postpartum or higher parity had a stronger positive relationship between milk and liver vitamin A than mothers in later postpartum or lower parity.
CONCLUSIONS: Our observations are consistent with life history tradeoffs and negate the assumption that maternal hepatic and milk vitamin A decline together. Rather, maternal liver vitamin A has a dynamic relationship with milk vitamin A, particularly depending on postpartum time and maternal parity.
Authors:
Masako Fujita; Bettina Shell-Duncan; Philip Ndemwa; Eleanor Brindle; Yun-Jia Lo; Yeri Kombe; Kathleen O'Connor
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-06-21
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  23     ISSN:  1520-6300     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-08-08     Completed Date:  2011-12-13     Revised Date:  2014-03-17    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  664-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Sectional Studies
Female
Humans
Kenya
Liver / chemistry*
Milk, Human / chemistry*
Models, Biological
Parity
Postpartum Period
Pregnancy
Time Factors
Vitamin A / analysis*,  blood
Grant Support
ID/Acronym/Agency:
R24 HD042828-10/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
11103-57-4/Vitamin A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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