Document Detail

Vitamin A-dependent transcriptional activation of the nuclear factor of activated T cells c1 (NFATc1) is critical for the development and survival of B1 cells.
MedLine Citation:
PMID:  21187378     Owner:  NLM     Status:  MEDLINE    
B1 cells represent a distinct subset of B cells that produce most of the natural serum IgM and much of the gut IgA and function as an important component of early immune responses to pathogens. The development of B1 cells depends on the nuclear factor of activated T cells c1 (NFATc1), a transcription factor abundantly expressed by B1 cells but not by conventional B2 cells. However, the factors that regulate the expression of NFATc1 in B1 cells remain unknown. Here we show that a vitamin A-deficient diet results in reduction of NFATc1 expression in B1 cells and almost complete loss of the B1 cell compartment. As a consequence, vitamin A-deficient mice have reduced serum IgM and are unable to mount T cell-independent antibody responses against bacterial antigens. We demonstrate that injection of all-trans retinoic acid induces the expression of NFATc1, particularly from the constitutive P2 promoter, and leads to the increase of the B1 cells. Thus, the retinoic acid-dependent pathway is critical for regulating NFATc1 expression and for maintenance of the natural memory B cell compartment.
Mikako Maruya; Keiichiro Suzuki; Hanae Fujimoto; Michio Miyajima; Osami Kanagawa; Teruhiko Wakayama; Sidonia Fagarasan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-27
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  108     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-12     Completed Date:  2011-02-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  722-7     Citation Subset:  IM    
Laboratory for Mucosal Immunity, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama 230-0045, Japan.
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MeSH Terms
B-Lymphocytes / metabolism*
Cell Proliferation
Cell Separation
Flow Cytometry / methods
Gene Expression Regulation*
Mice, Transgenic
NFATC Transcription Factors / metabolism*
Receptors, Retinoic Acid / metabolism
T-Lymphocytes / metabolism*
Transcription, Genetic
Transcriptional Activation*
Vitamin A / metabolism*
Reg. No./Substance:
0/NFATC Transcription Factors; 0/Nfatc1 protein, mouse; 0/Receptors, Retinoic Acid; 11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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