Document Detail

Vitamin A deficiency is associated with HCV chronic infection and with unresponsiveness to interferon based antiviral therapy.
MedLine Citation:
PMID:  23213086     Owner:  NLM     Status:  Publisher    
Recent data suggest that vitamin A modulate the expression of type I interferon receptor enhancing the anti replication effect of interferon-α on hepatitis C virus (HCV). This study aimed to investigate the prevalence of vitamin A deficiency among patients with chronic HCV infection and to assess whether vitamin A deficiency could be associated with unresponsiveness to interferon based antiviral therapy. The analysis included 199 consecutive treatment-naïve chronic hepatitis C patients in whom pre-treatment serum vitamin A and 25-OH vitamin D were measured; 119 healthy blood donors were used as controls. Median (inter-quartile range) serum vitamin A in HCV positive patients was significantly lower than in controls: 256 ng/mL (128-440) Vs 742 (624-942, p<0.0001). Overall sustained viral response was achieved in 122/199 patients, 46/109 infected by difficult to treat HCV genotypes. In these latter, 39/104 (37.5%) were non responders. At multivariate analysis, non response to antiviral therapy was predicted by carriage of IL-28B T/* genotypes, baseline serum levels of γGT >60 IU/mL, of HCV RNA >600.000 IU/mL, of vitamin A ≤100 ng/mL and the cumulative dose of ribavirin ≤80%. Seventeen patients (9.0%) had both serum levels of vitamin A ≤100 ng/mL and of vitamin D ≤20 ng/mL; the presence of the combined vitamin A and D deficiency was found to be a strong independent predictor of non response to antiviral therapy. Conclusions: a high percentage of patients with chronic HCV infection present serum vitamin A deficiency. This condition is associated with non response to antiviral therapy. (HEPATOLOGY 2012.).
Davide Bitetto; Nadia Bortolotti; Edmondo Falleti; Sara Vescovo; Carlo Fabris; Giovanna Fattovich; Annarosa Cussigh; Sara Cmet; Ezio Fornasiere; Elisa Ceriani; Mario Pirisi; Pierluigi Toniutto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  -     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Department of Medical Sciences Experimental and Clinical, Medical Liver Transplantation Unit, Internal Medicine, University of Udine, Italy.
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