| Vitamin deficiencies and neural-tube defects: human and animal studies. | |
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MedLine Citation:
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PMID: 1874949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The evidence for an association between vitamin deficiency in early pregnancy and the prevalence of neural-tube defects in humans is reviewed, with particular emphasis on the methodological problems encountered in conducting such studies. It is apparent that there is strong evidence for an association between maternal vitamin status and the outcome of pregnancy, but this is not universally accepted, due to ethical and practical constraints on the design of the studies. There are also problems in obtaining precise information from experiments on animals in vivo. By culturing rat embryos in dialysed serum in which the micromolecular component is defined, it has been possible to demonstrate that significant numbers of neural-tube defects can be produced by the deficiency of a single vitamin (inositol), and that multiple vitamin deficiency produces a further significant increase in the frequency of such defects. |
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Authors:
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D L Cockroft |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 6 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-09-26 Completed Date: 1991-09-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 148-57 Citation Subset: IM |
Affiliation:
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Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avitaminosis / complications* Culture Techniques Diet / adverse effects Embryo, Mammalian / drug effects Female Humans Microscopy, Electron, Scanning Neural Tube Defects / etiology* Pregnancy Rats Vitamins / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vitamins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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