| Vitamin d receptor activation: clinical outcomes. | |
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MedLine Citation:
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PMID: 21625107 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Vitamin D has been recognized for years as a key player in the control of bone metabolism through the regulation of calcium and phosphate homeostasis. Vitamin D deficiency appears to be common in the general population as a result of decreased dietary intake, diminished absorption, or limited exposure to sunlight. Vitamin D deficiency results in increased circulating levels of parathyroid hormone, which has several disadvantageous effects on bone metabolism. The intake of ordinary doses of vitamin D supplements appears to be associated with a decrease in total mortality rates. In the chronic kidney disease (CKD) population, vitamin D receptor (VDR) activation deficiency is even more severe than in a non-CKD population, with a 25-(OH) vitamin D level being an independent predictor of all-cause mortality. Similarly to nonrenal populations, the corrections of vitamin D deficiency/treatment with vitamin D is associated with better survival. Selective VDR activators appears to be better than calcitriol in terms of survival or adverse effects. |
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Authors:
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Adrian Covic; Mugurel Apetrii |
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Publication Detail:
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Type: Journal Article Date: 2011-05-23 |
Journal Detail:
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Title: Contributions to nephrology Volume: 171 ISSN: 1662-2782 ISO Abbreviation: Contrib Nephrol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513582 Medline TA: Contrib Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 166-71 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Nephrology Clinic, Parhon University Hospital, 'Gr.T. Popa' University of Medicine and Pharmacy, Iasi, Romania. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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