| Vitamin d and innate and adaptive immunity. | |
| | |
MedLine Citation:
|
PMID: 21419266 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
In the last 5 years there has been renewed interest in the health benefits of vitamin D. A central feature of this revival has been new information concerning the nonclassical effects of vitamin D. In particular, studies of the interaction between vitamin D and the immune system have highlighted the importance of localized conversion of precursor 25-hydroxyvitamin D (25OHD) to active 1,25-dihydroxyvitamin D (1,25(OH)(2)D) as a mechanism for maintaining antibacterial activity in humans. The clinical relevance of this has been endorsed by increasing evidence of suboptimal 25OHD status in populations across the globe. Collectively these observations support the hypothesis that vitamin D insufficiency may lead to dysregulation of human immune responses and may therefore be an underlying cause of infectious disease and immune disorders. The current review describes the key mechanisms associated with vitamin D metabolism and signaling for both innate immune (antimicrobial activity and antigen presentation) and adaptive immune (T and B lymphocyte function) responses. These include coordinated actions of the vitamin D-activating enzyme, 1α-hydroxylase (CYP27B1), and the vitamin D receptor (VDR) in mediating intracrine and paracrine actions of vitamin D. Finally, the review will consider the role of immunomodulatory vitamin D in human health, with specific emphasis on infectious and autoimmune disease. |
| | |
Authors:
|
Martin Hewison |
Related Documents
:
|
12888446 - Nasal epithelial and inflammatory response to ozone exposure: a review of laboratory-ba... 19488556 - Rt-pcr cytokine study in patients with allergic rhinitis. 10719286 - The role of lymphocytes in allergic disease. 11359636 - Future treatments of allergic diseases and asthma. 21733316 - Saturated fatty acids activate microglia via toll-like receptor 4/nf-κb signalling. 16806046 - Cytokine-induced nitric-oxide-dependent apoptosis in mouse osteoblastic cells: involvem... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Vitamins and hormones Volume: 86 ISSN: 0083-6729 ISO Abbreviation: Vitam. Horm. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0413601 Medline TA: Vitam Horm Country: United States |
Other Details:
|
Languages: eng Pagination: 23-62 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin d regulation of immune function.
Next Document: Dendritic cells modified by vitamin d: future immunotherapy for autoimmune diseases.