| Vitamin d effects on lung immunity and respiratory diseases. | |
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MedLine Citation:
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PMID: 21419273 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Our understanding of vitamin D metabolism and biological effects has grown exponentially in recent years and it has become clear that vitamin D has extensive immunomodulatory effects. The active vitamin D generating enzyme, 1α-hydroxylase, is expressed by the airway epithelium, alveolar macrophages, dendritic cells, and lymphocytes indicating that active vitamin D can be produced locally within the lungs. Vitamin D generated in tissues is responsible for many of the immunomodulatory actions of vitamin D. The effects of vitamin D within the lungs include increased secretion of the antimicrobial peptide cathelicidin, decreased chemokine production, inhibition of dendritic cell activation, and alteration of T-cell activation. These cellular effects are important for host responses against infection and the development of allergic lung diseases like asthma. Epidemiological studies do suggest that vitamin D deficiency predisposes to viral respiratory tract infections and mycobacterial infections and that vitamin D may play a role in the development and treatment of asthma. Randomized, placebo-controlled trials are lacking but ongoing. |
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Authors:
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Sif Hansdottir; Martha M Monick |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vitamins and hormones Volume: 86 ISSN: 0083-6729 ISO Abbreviation: Vitam. Horm. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413601 Medline TA: Vitam Horm Country: United States |
Other Details:
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Languages: eng Pagination: 217-37 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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