| Vitamin d as a T-cell modulator in multiple sclerosis. | |
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MedLine Citation:
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PMID: 21419282 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Vitamin D is a potent immune modulator, keeping the T-cell compartment in a more tolerogenic state. Multiple sclerosis (MS), a disease in which an autoreactive T-cell response contributes to inflammation in the central nervous system, has been associated with vitamin D deficiency. The effects of vitamin D on the immune system are believed to be an important driver of this association. In this chapter, we elaborate on vitamin D as a modulator of the T-cell response. This discussion will be placed in the perspective of MS as a T-cell-mediated disease and in the perspective of the numerous association studies on vitamin D deficiency and multiple health outcomes. We conclude that there is a firm experimental and epidemiological basis supporting the model of vitamin D as a physiological immune modulator, on which intervention studies assessing clinical and immunological outcome measures should be designed. |
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Authors:
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Joost Smolders; Jan Damoiseaux |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vitamins and hormones Volume: 86 ISSN: 0083-6729 ISO Abbreviation: Vitam. Horm. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413601 Medline TA: Vitam Horm Country: United States |
Other Details:
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Languages: eng Pagination: 401-28 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Internal Medicine, Division of Clinical and Experimental Immunology, Maastricht University Medical Center, Maastricht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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