Document Detail

Vitamin A and beta-carotene supply of women with gemini or short birth intervals: a pilot study.
MedLine Citation:
PMID:  17103079     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An adequate supply of vitamin A during pregnancy and breastfeeding plays an important role for development of foetus and neonate, especially in lung development and function. AIM OF THE STUDY: Aim of this pilot study was to analyze vitamin A and beta-carotene status and to investigate the contribution of nutrition to the vitamin A and beta-carotene supply in mother-infant pairs of gemini or births within short birth intervals. METHODS: Twenty-nine volunteers aged between 21 and 36 years were evaluated for 48 h after delivery. During this time frame a food frequency protocol considering 3 months retrospective was obtained from all participants. In order to establish overall supply retinol and beta-carotene levels were determined in maternal plasma, cord blood and colostrum via HPLC analysis. RESULTS: Regardless of the high to moderate socio-economic background, 27.6% of participants showed plasma retinol levels below 1.4 micromol/l which can be taken as borderline deficiency. In addition, 46.4% showed retinol intake <66% of RDA and 50.0% did not consume liver at all although liver contributes as a main source for preformed retinol. Despite high total carotenoid intake of 6.9 +/- 3.6 mg/d, 20.7% of mothers showed plasma levels <0.5 micromol/l beta-carotene. Retinol and beta-carotene levels were highly significantly correlated between maternal plasma versus cord blood and colostrum. In addition, significantly lower levels were found in cord blood (31.2 +/- 13.0% (retinol), 4.1 +/- 1.4% (beta-carotene) compared with maternal plasma. CONCLUSIONS: Despite the fact that vitamin A and beta-carotene rich food is generally available, risk groups for low vitamin A supply exist in the western world.
Christiane Schulz; Ulrike Engel; Rolf Kreienberg; Hans Konrad Biesalski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-10
Journal Detail:
Title:  European journal of nutrition     Volume:  46     ISSN:  1436-6207     ISO Abbreviation:  Eur J Nutr     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-01     Completed Date:  2007-10-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  12-20     Citation Subset:  IM    
BioTeSys GmbH, Schelztorstr. 54-56, 73728 Esslingen, Germany.
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MeSH Terms
Birth Intervals*
Chromatography, High Pressure Liquid / methods
Colostrum / chemistry
Cross-Sectional Studies
Dietary Supplements
Fetal Blood / chemistry
Infant, Newborn
Maternal Nutritional Physiological Phenomena / physiology*
Nutrition Policy
Nutritional Requirements
Nutritional Status*
Pilot Projects
Pregnancy / blood*
Socioeconomic Factors
Vitamin A / administration & dosage,  blood*
beta Carotene / administration & dosage,  blood*
Reg. No./Substance:
11103-57-4/Vitamin A; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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