Document Detail

Vitamin K status in patients with short bowel syndrome.
MedLine Citation:
PMID:  22633417     Owner:  NLM     Status:  Publisher    
BACKGROUND & AIMS: Available evidence suggests that patients with short bowel syndrome (SBS) might be at risk of vitamins A, D, E and B(1) deficiency. However, there is little clinical data describing the vitamin K status. Therefore, in the present study we aimed to assess the body resources of vitamin K in a subset of SBS patients. METHODS: The study comprised 33 patients aged 1 month to 16 years. PIVKA-II concentrations were determined in all subjects. RESULTS: In all studied subjects, coagulation parameters were normal. PIVKA-II levels indicative of vitamin K deficiency was found in 3 (9.1%) SBS patients. One patient had been receiving an additional intravenous vitamin K dose of 5 mg/week. In all SBS patients with cirrhosis and cholestasis, PIVKA-II concentrations were low (<2 ng/ml). However, all patients with severe liver disease were receiving vitamin K several times a month. CONCLUSIONS: Vitamin K deficiency may appear in SBS patients.
Patrycja Krzyżanowska; Janusz Książyk; Małgorzata Kocielińska-Kłos; Elżbieta Banaś; Małgorzata Kaleta; Katarzyna Popińska; Tomasz Szczapa; Jarosław Walkowiak
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-26
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  -     ISSN:  1532-1983     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poland.
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