Document Detail

Vitamin K prophylaxis and late vitamin K deficiency bleeding in infants: fifth nationwide survey in Japan.
MedLine Citation:
PMID:  21518125     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In 1980, the first nationwide survey on late vitamin K deficiency bleeding (VKDB) in infants was conducted in Japan, and it was followed by the second, third and fourth nationwide surveys in 1985, 1988 and 1991, respectively. The fifth nationwide survey was designed to ascertain the epidemiology of late VKDB between January 1999 and December 2004.
PATIENTS AND METHODS: Questionnaires were sent to 2161 hospitals in Japan that employed members of the Japan Pediatric Society in March 2005. Responses were received from 1373 hospitals, for a response rate of 63.5%.
RESULTS: The total number of reported cases was 71, including 21 idiopathic type and 16 secondary type. The incidence of late VKDB was estimated to be 1.9 cases per 100,000 births (95% confidence interval: 1.2-3.0) during this survey period. In 34 cases, the presence or absence of any underlying disease was not clarified. A total of 67/71 infants were entirely breast-fed. Intracranial hemorrhaging was observed in 26 (63.4%) out of 41 infants whose bleeding sites were described in the questionnaires. In 63 cases (88.7%) of late VKDB found in the present survey, however, vitamin K had been given at least once either during or after the neonatal period.
CONCLUSIONS: A reevaluation of the current prophylaxis strategy for late VKDB in infants is necessary.
Daijiro Takahashi; Akira Shirahata; Susumu Itoh; Yukihiro Takahashi; Tomizo Nishiguchi; Yoshio Matsuda
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  53     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  2012-05-22     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  897-901     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.
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MeSH Terms
Antifibrinolytic Agents / administration & dosage,  therapeutic use
Infant, Newborn
Japan / epidemiology
Survival Rate / trends
Vitamin K / administration & dosage,  therapeutic use*
Vitamin K Deficiency / epidemiology,  prevention & control*
Vitamin K Deficiency Bleeding / epidemiology,  prevention & control*
Reg. No./Substance:
0/Antifibrinolytic Agents; 12001-79-5/Vitamin K
Comment In:
Pediatr Int. 2014 Feb;56(1):127-8   [PMID:  24548202 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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