Document Detail

Vitamin K: a practical guide to the dietary management of patients on warfarin.
MedLine Citation:
PMID:  10568341     Owner:  NLM     Status:  MEDLINE    
Warfarin has been successfully used in the medical management of thromboembolic disease for nearly six decades. It is widely assumed that a dietary vitamin K-warfarin interaction exists. To avoid this potential interference with the efficacy of warfarin in stable anticoagulation, patients typically receive instructions to consume a constant dietary intake of vitamin K. While dark, green vegetables are primary sources of dietary vitamin K, these foods are not commonly consumed on a daily basis in the United States. However, there still exists dietary resistance to warfarin that is attributable to vitamin K. Based on food analysis studies on vitamin K, it is now known that dietary vitamin K is found in certain plant oils and prepared foods containing these plant oils, such as baked goods, margarines, and salad dressings. The preparation of foods with vitamin K-rich oils may also contribute to a diet-warfarin interaction, although this has yet to be confirmed in a clinical trial. A dose-response of vitamin K on the effect of warfarin anticoagulation has not yet been established. However, there are sufficient data to suggest that a constant dietary intake of vitamin K that meets current dietary recommendations of 65-80 micrograms/day is the most acceptable practice for patients on warfarin therapy. Vitamin K composition data for commonly consumed foods are now available and may facilitate successful anticoagulation for patients being treated with warfarin.
S L Booth; M A Centurelli
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  57     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  288-96     Citation Subset:  IM    
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
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MeSH Terms
Anticoagulants / pharmacology*
Drug Interactions
Food Analysis
Vitamin K / administration & dosage*,  analysis,  therapeutic use
Warfarin / pharmacology*
Reg. No./Substance:
0/Anticoagulants; 12001-79-5/Vitamin K; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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