Document Detail

Vitamin K and childhood cancer: a population based case-control study in Lower Saxony, Germany.
MedLine Citation:
PMID:  8696195     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To confirm or refute a possible association of parenteral vitamin K prophylaxis and childhood cancer.
DESIGN: Population based case-control study. Comparison of vitamin K exposure in children with leukaemia or other common tumours with two control groups.
SETTING: State of Lower Saxony (north western part of Germany); case recruitment from the German childhood cancer registry.
SUBJECTS: 272 children with leukaemia, nephroblastoma, neuroblastoma, rhabdomyosarcoma, and tumours of the central nervous system diagnosed between 1 July 1988 and 30 June 1993; children were aged between 30 days and 15 years at diagnosis. 334 population based controls without diagnoses of cancer matched to the leukaemia cases for age and sex.
MAIN EXPOSURE MEASURES: Parenteral vitamin K prophylaxis (intramuscular and subcutaneous) versus oral and no vitamin K prophylaxis.
RESULTS: An association between parenteral vitamin K exposure and childhood cancer (leukaemias and other tumours combined) could not be confirmed (odds ratio 1.04, 95% confidence interval 0.74 to 1.48). For leukaemias the observed odds ratio was only 0.98 (0.64 to 1.50) (comparison of leukaemia cases with local controls 1.24 (0.68 to 2.25); state controls 0.82 (0.50 to 1.36)). These odds ratios remained almost unchanged when several potential confounders were considered in the logistic regression model.
CONCLUSIONS: This population based study adds substantial evidence that there is no association between parenteral vitamin K and childhood cancer.
R von Kries; U Göbel; A Hachmeister; U Kaletsch; J Michaelis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  313     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-09-04     Completed Date:  1996-09-04     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  AIM; IM    
Kinderklinik, Heinrich-Heine-Universität, Düsseldorf, Germany.
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MeSH Terms
Case-Control Studies
Central Nervous System Neoplasms / etiology
Child, Preschool
Germany / epidemiology
Infant, Newborn
Injections, Intramuscular
Injections, Subcutaneous
Kidney Neoplasms / etiology
Leukemia / etiology
Neoplasms / etiology*
Neuroblastoma / etiology
Population Surveillance
Rhabdomyosarcoma / etiology
Risk Factors
Vitamin K / administration & dosage,  adverse effects*
Vitamin K Deficiency / prevention & control
Wilms Tumor / etiology
Reg. No./Substance:
12001-79-5/Vitamin K
Comment In:
BMJ. 1996 Jul 27;313(7051):179-80   [PMID:  8696177 ]
BMJ. 1996 Nov 2;313(7065):1147   [PMID:  8916721 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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