Document Detail

Vitamin E and vitamin C in the treatment of idiopathic sudden sensorineural hearing loss.
MedLine Citation:
PMID:  17851951     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The results of this study suggest that the administration of vitamin E and vitamin C to patients with idiopathic sudden sensorineural hearing loss (ISSHL) has beneficial effects by reducing the level of reactive oxygen metabolites produced by inner ear ischaemia and reperfusion injury after treatment. OBJECTIVES: The purpose of this study was to investigate the efficacy of antioxidant vitamin E and vitamin C in the treatment of ISSHL. PATIENTS AND METHODS: In a retrospective chart review, a total of 87 patients were enrolled who fulfilled the following inclusion criteria: 1) sudden onset of sensorineural hearing loss, 2) cause of hearing loss unknown, 3) hearing loss did not fluctuate, 4) arithmetic mean of hearing levels at 250, 500, 1000, 2000 and 4000 Hz exceeded 40 dB and 5) treatment was started within 14 days from the onset of hearing loss. All the patients were treated with steroids and/or alprostadil. In the study group, patients additionally received vitamin E (tocopherol nicotinate, 600 mg/day) and vitamin C (1200 mg/day) orally. RESULTS: The hearing gain after therapy was 29.4 dB and the improvement rate was 63.3% in the study group, compared with 18.5 dB and 44.0% in the control group. Significant improvement was seen in the hearing gain and recovery rate in the study group.
Miyako Hatano; Naoki Uramoto; Yozo Okabe; Mitsuru Furukawa; Makoto Ito
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  128     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-07-24     Completed Date:  2008-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  116-21     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, Kouseiren Takaoka Hospital, Takaoka, Japan.
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MeSH Terms
Adenosine Triphosphate / therapeutic use
Alprostadil / therapeutic use
Antioxidants / therapeutic use*
Ascorbic Acid / therapeutic use*
Audiometry, Pure-Tone
Auditory Threshold / drug effects
Drug Therapy, Combination
Hearing Loss, Sudden / drug therapy*,  etiology
Middle Aged
Prednisolone / therapeutic use
Retrospective Studies
Tocopherols / therapeutic use*
Vitamin B 12 / therapeutic use
Reg. No./Substance:
0/Antioxidants; 1406-66-2/Tocopherols; 50-24-8/Prednisolone; 50-81-7/Ascorbic Acid; 56-65-5/Adenosine Triphosphate; 68-19-9/Vitamin B 12; 745-65-3/Alprostadil

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