Document Detail

Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary angioplasty (PTCA).
MedLine Citation:
PMID:  1541798     Owner:  NLM     Status:  MEDLINE    
To test whether alpha-tocopherol prevents restenosis following percutaneous transluminal coronary angioplasty (PTCA), we enrolled patients in a double-blind, placebo-controlled trial. Patients were randomized after successful PTCA to receive vitamin E in the form of dl-alpha-tocopherol, 1200 IU/day, orally vs an inactive placebo for 4 months. Patients' blood was analyzed at baseline and at 4 months post-PTCA for differences in plasma lipids, lipoproteins, apolipoproteins, alpha-tocopherol, retinol, beta-carotene and lipoperoxide concentrations. One hundred patients completed the protocol. No significant difference was found in any parameter except alpha-tocopherol level between the vitamin E group and the placebo group, verifying compliance. Follow-up cardiac catheterization was obtained in 83% of the patients receiving placebo and in 86% of the patients receiving dl-alpha-tocopherol. Including thallium and exercise stress testing, objective information was obtained for practically all the patients receiving dl-alpha-tocopherol or placebo. Restenosis was defined as the presence of a lesion with greater than or equal to 50% stenosis in a previously dilated artery segment and results were analyzed with respect to pre- and post-PTCA artery diameter, vessel diameter at follow-up, and restenosis rate. Patients receiving dl-alpha-tocopherol had a 35.5% restenosis angiographically documented vs 47.5% restenosis in patients receiving the placebo. The overall incidence of restenosis defined by an abnormal angiogram or thallium test or exercise stress test was 34.6% in patients receiving dl-alpha-tocopherol and 50% in patients receiving the placebo. This difference (p = 0.06) did not reach significance because of an inadequate sample size.
S J DeMaio; S B King; N J Lembo; G S Roubin; J A Hearn; H N Bhagavan; D S Sgoutas
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  11     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Andreas Gruentzig Cardiovascular Center, Department of Internal Medicine (Cardiology), Atlanta, GA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Apolipoproteins / blood
Cholesterol / blood
Coronary Angiography
Coronary Disease / epidemiology,  prevention & control*,  therapy
Double-Blind Method
Exercise Test
Follow-Up Studies
Lipids / blood*
Middle Aged
Prospective Studies
Risk Factors
Vitamin E / therapeutic use*
Reg. No./Substance:
0/Apolipoproteins; 0/Lipids; 1406-18-4/Vitamin E; 57-88-5/Cholesterol

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