Document Detail

Vitamin E supplementation, exercise and lipid peroxidation in human participants.
MedLine Citation:
PMID:  15248069     Owner:  NLM     Status:  MEDLINE    
The theoretical benefits of using antioxidant vitamin supplements to quench oxygen free radicals appear large. The major function of vitamin E is to work as a chain-breaking antioxidant in a fat soluble environment so as to protect polyunsaturated fatty acids within membrane phospholipids and in plasma lipoproteins. The purpose of this critical review was to determine whether vitamin E supplementation decreases exercise-induced lipid peroxidation in humans. If vitamin E alone is ineffective, researchers can turn their efforts to other individual antioxidants or combinations. Using the search words "vitamin E", "exercise", "lipid peroxidation" and "antioxidant", all relevant studies since 1985 were identified through a computer search using Pub Med and Sport Discuss databases. Additional articles were reviewed from the reference list of the retrieved articles. Nine vitamin E studies met the criteria of using human participants in an experimental design. Studies were analyzed to determine the strength of evidence regarding the efficacy of vitamin E supplementation. Strength of evidence was based on: (1) number of participants, (2) intensity of the exercise test, (3) type of research design, (4) other controls, (5) the biomarker of lipid peroxidation, (6) the timing of the biomarker measurement, (7) measurement of vitamin E status and (8) correction for plasma volume change. Overall, the six studies showing no effect of vitamin E supplementation had a much higher total score (67) in comparison to the three studies showing positive effects (38). Although limitations have plagued much of the research, vitamin E supplementation does not appear to decrease exercise-induced lipid peroxidation in humans.
P Viitala; I J Newhouse
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Publication Detail:
Type:  Journal Article; Review     Date:  2004-07-10
Journal Detail:
Title:  European journal of applied physiology     Volume:  93     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-11-19     Completed Date:  2005-07-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  108-15     Citation Subset:  IM    
School of Kinesiology, Lakehead University, 955 Oliver Road, P7B 5E1, Thunder Bay, Ontario, Canada.
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MeSH Terms
Administration, Oral
Antioxidants / administration & dosage
Clinical Trials as Topic*
Dietary Supplements*
Exercise / physiology*
Lipid Peroxidation / drug effects*,  physiology*
Physical Exertion / drug effects,  physiology*
Vitamin E / administration & dosage*
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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