| Vitamin E protects against the development of radiation-induced pulmonary fibrosis in rats. | |
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MedLine Citation:
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PMID: 17433970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate whether the application of vitamin E with or without pentoxifylline could modify the development of radiation-induced pulmonary fibrosis. MATERIALS AND METHODS: Wistar albino rats were supplemented with either vitamin E or pentoxifylline or with both vitamin E and pentoxifylline after a single dose of 14 Gy thoracic irradiation. Supplementation was started the day after irradiation and continued until the rats were sacrificed. As a quantitative end point, the extent of fibrosis was evaluated with a scale from 0 (normal lung) to 8 (total fibrous obliteration of the field) at pathological examination of the lung tissue. RESULTS: A significant reduction in fibrosis was obtained in the group of rats supplemented with vitamin E with or without pentoxifylline, when compared with the group that had irradiation only. CONCLUSION: This experimental study showed that vitamin E supplementation immediately after irradiation protected rats against radiation-induced pulmonary fibrosis. The combination with pentoxifylline was more effective, although pentoxifylline itself had limited efficacy, which was not statistically significant. |
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Authors:
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N S Bese; F Munzuroglu; B Uslu; S Arbak; G Yesiladali; N Sut; T Altug; A Ober |
Publication Detail:
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Type: Journal Article Date: 2007-01-12 |
Journal Detail:
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Title: Clinical oncology (Royal College of Radiologists (Great Britain)) Volume: 19 ISSN: 0936-6555 ISO Abbreviation: Clin Oncol (R Coll Radiol) Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-16 Completed Date: 2007-06-14 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9002902 Medline TA: Clin Oncol (R Coll Radiol) Country: England |
Other Details:
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Languages: eng Pagination: 260-4 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Cerrahpasa Medical School, Istanbul University, 34098 Cerrahpasa, Istanbul, Turkey. nuranbese@superonline.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / administration & dosage, therapeutic use* Dietary Supplements Drug Therapy, Combination Female Fibrosis / prevention & control Free Radical Scavengers / administration & dosage, therapeutic use* Lung Neoplasms / prevention & control* Neoplasms, Radiation-Induced / prevention & control* Pentoxifylline / administration & dosage, therapeutic use* Radiation Dosage Rats Rats, Wistar Vitamin E / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radical Scavengers; 1406-18-4/Vitamin E; 6493-05-6/Pentoxifylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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