Document Detail

Vitamin E prevents deleterious effects of di (2-ethyl hexyl) phthalate, a plasticizer used in PVC blood storage bags.
MedLine Citation:
PMID:  15462179     Owner:  NLM     Status:  MEDLINE    
Vitamin E administration prevented DEHP induced deleterious effects like (i) degenerative changes in the brain and thyroid, (ii) decrease in the activity of neuronal membrane Na+ - K+ ATPase, (iii) decrease in the concentration of insulin, cortisol and TSH, and (iv) the increase in T3 and T4 in female Albino rats. The results suggest use of vitamin E to prevent harmful effects of repeated transfusion of DEHP containing blood as in thalassemia patient. The possibility of using vitamin E to prevent the harmful effects of repeated transfusion of DEHP containing blood, as in thalassemia patients, is discussed.
C R Dhanya; N S Gayathri; K Mithra; K V Neelakantan Nair; P A Kurup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  42     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  871-5     Citation Subset:  IM    
Metabolic Disorders Research Center, Trivandrum 695014, India.
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MeSH Terms
Blood Glucose / metabolism
Blood Preservation / methods*
Blood Transfusion / methods*
Diethylhexyl Phthalate / pharmacology*
Hydrocortisone / metabolism
Insulin / metabolism
Plasticizers / chemistry*
Polyvinyl Chloride / chemistry*
Rats, Wistar
Sodium-Potassium-Exchanging ATPase / metabolism
Thyrotropin / metabolism
Vitamin E / therapeutic use*
Reg. No./Substance:
0/Blood Glucose; 0/Plasticizers; 11061-68-0/Insulin; 117-81-7/Diethylhexyl Phthalate; 1406-18-4/Vitamin E; 50-23-7/Hydrocortisone; 9002-71-5/Thyrotropin; 9002-86-2/Polyvinyl Chloride; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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