| Vitamin E improves learning performance and changes the expression of nitric oxide-producing neurons in the brains of diabetic rats. | |
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MedLine Citation:
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PMID: 20138920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of chronic administration of vitamin E on nitric oxide (NO)-producing neurons in the brains of streptozotocin (STZ)-induced diabetic rats using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. We further evaluated the effects of diabetes and vitamin E treatment on experimental anxiety and memory processes using the elevated plus maze (EPM) Trial 1/2 protocol. Wistar rats were divided into four groups: normoglycemics (N), normoglycemics treated with vitamin E (NVE), diabetics (D), and diabetics treated with vitamin E (DVE). Diabetes mellitus was induced by a single intraperitoneal injection of STZ (35mg/kg). Vitamin E (100mg/kg) or vehicle was administered orally by gavage (1ml/kg) once each day for 7 weeks. After behavioral testing, the dentate gyrus of the hippocampus (DG), striatum, paraventricular nucleus of the hypothalamus (PVN), supraoptic nucleus (SON), and dorsolateral periaqueductal grey (DLPAG) were analyzed for NADPH-d histochemistry. STZ-induced diabetic rats exhibited decreased locomotor activity and cognitive impairment compared with normoglycemic controls. The number of NADPH-d-positive neurons was increased in the DG, striatum, and DLPAG of diabetic rats. An increase in soma area was detected in all structures analyzed (DG, striatum, PVN, SON, and DLPAG) of STZ-induced diabetic animals. The present study showed that chronic administration of vitamin E ameliorates memory in STZ-induced diabetic rats and revealed that NOS-producing neurons have an increased soma area which can be restored, at least partially, by vitamin E treatment. These results suggest the potential use of vitamin E as an adjuvant therapy for the prevention and treatment of diabetic conditions. |
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Authors:
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D?bora Comin; Lucas Gazarini; Jaqueline Nielisis Zanoni; Humberto Milani; R?bia Maria Weffort de Oliveira |
Publication Detail:
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Type: Journal Article Date: 2010-02-06 |
Journal Detail:
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Title: Behavioural brain research Volume: 210 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 38-45 Citation Subset: IM |
Affiliation:
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Department of Pharmacy and Pharmacology, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anxiety / drug therapy, metabolism Brain / metabolism*, pathology Cognition Disorders / diet therapy, metabolism, pathology Diabetes Mellitus, Experimental / diet therapy*, metabolism, pathology Learning / physiology* Male Maze Learning / physiology Memory / physiology Motor Activity / physiology NADP / metabolism Neurons / metabolism*, pathology Nitric Oxide / metabolism* Random Allocation Rats Rats, Wistar Vitamin E / metabolism, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 1406-18-4/Vitamin E; 53-59-8/NADP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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