Document Detail


Vitamin E deficiency and neurologic disease in adults with cystic fibrosis.
MedLine Citation:
PMID:  3592448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the cases of two adult patients with cystic fibrosis affecting the pancreas and liver, who also had severe vitamin E deficiency and neurologic disease. The most prominent clinical features were abnormal eye movements, diminished reflexes, decreased vibratory and position sense, ataxia, and muscle weakness. Treatment with intramuscular injections of vitamin E partially corrected the neurologic deficits. Vitamin E absorption tests documented severe malabsorption, which was later alleviated by the addition of dessicated ox bile to the regimen of alpha-tocopheryl acetate. These studies suggest that a decreased intraluminal concentration of bile salts is an important factor in the development of severe vitamin E deficiency and in the poor response to oral replacement therapy that is seen in some patients with cystic fibrosis.
Authors:
M D Sitrin; F Lieberman; W E Jensen; A Noronha; C Milburn; W Addington
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  107     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-07-20     Completed Date:  1987-07-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Bile Acids and Salts / therapeutic use
Cystic Fibrosis / complications*
Female
Humans
Injections, Intramuscular
Malabsorption Syndromes / physiopathology*
Nervous System Diseases / etiology*,  therapy
Tocopherols
Vitamin E / analogs & derivatives,  therapeutic use
Vitamin E Deficiency / drug therapy,  etiology*,  physiopathology
alpha-Tocopherol* / analogs & derivatives*
Grant Support
ID/Acronym/Agency:
2-MO1-RR00055/RR/NCRR NIH HHS; 5-P30-AM-26678/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 1406-18-4/Vitamin E; 1406-66-2/Tocopherols; 59-02-9/alpha-Tocopherol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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