Document Detail

Vitamin E deficiency fails to affect myocardial performance during in vivo ischemia-reperfusion.
MedLine Citation:
PMID:  11214354     Owner:  NLM     Status:  MEDLINE    
Vitamin E content of cardiac tissue has been proposed to play a major role in the damage caused by myocardial ischemia-reperfusion (I-R). Previous studies using in vitro models have examined vitamin E deficiency and I-R-induced myocardial damage with equivocal results. The purpose of this study was to use an in vivo model of myocardial I-R to determine the effects of vitamin E deficiency on myocardial I-R-induced damage. Female Sprague-Dawley rats (4-mo old) were assigned to either: 1) control diet (CON), or 2) vitamin E deficient diet (VE-DEF). The CON diet was prepared to meet AIN-93M standards, which contains 75 IU vitamin E/kg diet. The VE-DEF diet was the AIN-93M diet prepared with tocopherol stripped corn oil and no vitamin E. Following a 14-week feeding period, significant differences (p < 0.05) existed in mean myocardial VE levels between groups (mean values +/- SEM: CON = 48.2 +/- 3.5; VE-DEF = 12.4 +/- 1.4 micrograms VE/g wet weight). Animals from both experimental groups were subjected to an in vivo I-R protocol consisting of 25 minutes of left coronary artery occlusion followed by 10 minutes of reperfusion. No group differences (p > 0.05) existed in cardiac performance (peak arterial pressure or ventricular work) or the incidence of ventricular arrhythmias during the I-R protocol. VE-DEF animals had significantly higher (p < 0.05) levels of myocardial lipid peroxidation and lower (p < 0.05) protein thiols following I-R compared to the CON animals. These data suggest that although vitamin E deficiency increases oxidative damage resulting from myocardial I-R, it does not affect cardiac performance during the insult.
J S Coombes; S K Powers; H A Demirel; K L Hamilton; J Jessup; H K Vincent; R A Shanely
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  70     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-14     Completed Date:  2001-05-17     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  293-300     Citation Subset:  IM    
School of Human Movement Studies, University of Queensland, St Lucia, Qld., Australia, 4072.
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MeSH Terms
Animal Feed
Benzene Derivatives / analysis
Disease Models, Animal
Free Radicals / metabolism
Heart / physiology*
Lipid Peroxidation / drug effects
Myocardial Contraction / drug effects*
Myocardial Reperfusion Injury / drug therapy*,  metabolism,  physiopathology
Myocardium / chemistry*
Rats, Sprague-Dawley
Thiobarbituric Acid Reactive Substances / analysis
Ventricular Function / drug effects
Vitamin E / analysis,  pharmacology*,  therapeutic use
Vitamin E Deficiency / complications*,  physiopathology
Reg. No./Substance:
0/Benzene Derivatives; 0/Free Radicals; 0/Thiobarbituric Acid Reactive Substances; 1406-18-4/Vitamin E; 80-15-9/cumene hydroperoxide

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