Document Detail

Vitamin E bioavailability from fortified breakfast cereal is greater than that from encapsulated supplements.
MedLine Citation:
PMID:  14684402     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Conflicting results from vitamin E intervention studies suggest supplemental vitamin E malabsorption. OBJECTIVE: We compared vitamin E bioavailability from a supplement with that from a fortified breakfast cereal. DESIGN: Vitamin E bioavailability was evaluated by using deuterium-labeled all-rac-alpha-tocopherol in three 4-d trials (2 wk apart). Five fasting subjects sequentially consumed the following (with 236 mL fat-free milk): 400 IU d(9)-alpha-tocopheryl acetate (400-IU capsule), 41 g ready-to-eat wheat cereal containing 30 IU d(9)-alpha-tocopheryl acetate (30-IU cereal), and 45 g cereal containing 400 IU d(9)-alpha-tocopheryl acetate (400-IU cereal). Five months later (trial 4), they consumed a 400-IU capsule with 41 g vitamin E-free cereal. Blood was obtained up to 72 h after the start of each trial. RESULTS: The mean (+/-SD) vitamin E bioavailabilities of the 30-IU cereal and the 400-IU cereal were 6 +/- 2 and 26 +/- 8 times, respectively, the vitamin E bioavailability of the 400-IU capsule. The areas under the 0-72-h d(9)-alpha-tocopherol curves for the 400-IU capsule, the 30-IU cereal, and the 400-IU cereal were 30 +/- 7, 153 +/- 43, and 765 +/- 164 micro mol. h/L (all trial comparisons, P < 0.0001). In trial 4, 3 subjects barely responded and 2 subjects had areas under the curve that were similar to their 400-IU cereal responses. CONCLUSION: The low bioavailability of vitamin E from the 400-IU capsule and the variability observed when the capsule was consumed with cereal suggest that encapsulated vitamin E is poorly absorbed when consumed with a low-fat meal and that bioavailability can be enhanced by food fortification with vitamin E.
Scott W Leonard; Carolyn K Good; Eric T Gugger; Maret G Traber
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  79     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-19     Completed Date:  2004-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-92     Citation Subset:  AIM; IM    
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
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MeSH Terms
Biological Availability
Food, Fortified*
Vitamin E / administration & dosage,  blood,  pharmacokinetics*
Reg. No./Substance:
0/Capsules; 1406-18-4/Vitamin E
Comment In:
Am J Clin Nutr. 2004 Sep;80(3):784-5; author reply 785-6   [PMID:  15321826 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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