| Vitamin E and apoptosis. | |
| | |
MedLine Citation:
|
PMID: 17628180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Vitamin E is a generic term that refers to a family of compounds that is further divided into two subgroups called tocopherols and tocotrienols. All natural forms of tocopherols and tocotrienols are potent antioxidants that regulate peroxidation reactions and controls free radical production within the body. However, it is now firmly established that many of the biological actions mediated by individual vitamin E isoforms are not dependent on their antioxidant activity. Furthermore, synthetic ether derivatives of vitamin E that no longer possess antioxidant activity also display a wide range of biological activities. One of the most intriguing therapeutic applications for natural vitamin E and vitamin E derivatives currently being investigated is their use as anticancer agents. Specific forms of vitamin E display potent apoptotic activity against a wide range of cancer cell types, while having little or no effect on normal cell function or viability. Experimental studies have also determined that the intracellular mechanisms mediating the apoptotic effects of specific vitamin E compounds display great diversity in different types of caner cells and has been found to restore multidrug resistant tumor cells sensitivity to chemotherapeutic agents. These findings strongly suggest that some natural and synthetic analogues of vitamin E can be used effectively as anticancer therapy either alone or in combination to enhance the therapeutic efficacy and reduce toxicity of other anticancer agents. |
| | |
Authors:
|
Paul W Sylvester |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Vitamins and hormones Volume: 76 ISSN: 0083-6729 ISO Abbreviation: Vitam. Horm. Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-07-13 Completed Date: 2007-09-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0413601 Medline TA: Vitam Horm Country: United States |
Other Details:
|
Languages: eng Pagination: 329-56 Citation Subset: IM |
Affiliation:
|
College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antioxidants* / chemistry, metabolism, pharmacology Apoptosis* / drug effects Humans Neoplasms* / drug therapy, metabolism Vitamin E* / chemistry, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 1406-18-4/Vitamin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Addition products of alpha-tocopherol with lipid-derived free radicals.
Next Document: Vitamin E during pre- and postnatal periods.