Document Detail


Vitamin E analogues as inducers of apoptosis: implications for their potential antineoplastic role.
MedLine Citation:
PMID:  11523588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent evidence suggests that vitamin E and its analogues, which have been used for many years as antioxidants, may not only protect cells from free radical damage but also induce apoptotic cell death in various cell types. While alpha-tocopherol (alpha-TOH) is mainly known as an anti-apoptotic agent, its redox-silent analogues either have no influence on cell survival (alpha-tocopheryl acetate, alpha-TOA), or induce apoptosis (alpha-tocopheryl succinate, alpha-TOS). Although precise mechanisms of apoptosis induction by alpha-TOS remain to be elucidated, there is evidence that this process involves both the antiproliferative and membrane destabilising activities of the agent. Alpha-TOS has been shown to induce apoptosis in malignant cell lines but not, in general, in normal cells, and to inhibit tumorigenesis in vivo. These features suggest that this semi-synthetic analogue of vitamin E could be a promising antineoplastic agent.
Authors:
J Neuzil; T Weber; A Terman; C Weber; U T Brunk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Redox report : communications in free radical research     Volume:  6     ISSN:  1351-0002     ISO Abbreviation:  Redox Rep.     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-28     Completed Date:  2002-02-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9511366     Medline TA:  Redox Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
Affiliation:
Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany. jneuzil@klp.med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy
Animals
Antineoplastic Agents / pharmacology*,  therapeutic use
Antioxidants / pharmacology*,  therapeutic use
Apoptosis / drug effects*
Cell Cycle / drug effects
Colonic Neoplasms / drug therapy
Drug Screening Assays, Antitumor
Free Radical Scavengers / pharmacology,  therapeutic use
Free Radicals
Gene Expression Regulation / drug effects
Humans
Intestinal Mucosa / drug effects
Intracellular Membranes / drug effects
Lysosomes / drug effects
Macrophages / drug effects
Mice
Mice, Nude
Mitochondria / drug effects
Molecular Structure
Neoplastic Stem Cells / drug effects
Oxidation-Reduction
Protein Kinase C / physiology
Reactive Oxygen Species
Signal Transduction / drug effects
Stem Cells / drug effects
Tocopherols
Tumor Cells, Cultured / drug effects
Vitamin E / analogs & derivatives*,  pharmacology*,  therapeutic use
Xenograft Model Antitumor Assays
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antioxidants; 0/Free Radical Scavengers; 0/Free Radicals; 0/Reactive Oxygen Species; 1406-18-4/Vitamin E; 1406-66-2/Tocopherols; EC 2.7.11.13/Protein Kinase C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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