Document Detail

Vitamin E analogues as inducers of apoptosis: implications for their potential antineoplastic role.
MedLine Citation:
PMID:  11523588     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that vitamin E and its analogues, which have been used for many years as antioxidants, may not only protect cells from free radical damage but also induce apoptotic cell death in various cell types. While alpha-tocopherol (alpha-TOH) is mainly known as an anti-apoptotic agent, its redox-silent analogues either have no influence on cell survival (alpha-tocopheryl acetate, alpha-TOA), or induce apoptosis (alpha-tocopheryl succinate, alpha-TOS). Although precise mechanisms of apoptosis induction by alpha-TOS remain to be elucidated, there is evidence that this process involves both the antiproliferative and membrane destabilising activities of the agent. Alpha-TOS has been shown to induce apoptosis in malignant cell lines but not, in general, in normal cells, and to inhibit tumorigenesis in vivo. These features suggest that this semi-synthetic analogue of vitamin E could be a promising antineoplastic agent.
J Neuzil; T Weber; A Terman; C Weber; U T Brunk
Related Documents :
23042518 - Barrier protective effects of rosmarinic acid on hmgb1-induced inflammatory responses i...
23267148 - Ros mediate proapoptotic and antisurvival activity of oleanane triterpenoid cddo-me in ...
22943568 - Deciphering the roles of macrophages in developmental and inflammation stimulated lymph...
23987998 - The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflamma...
9346888 - Cell-specific regulation of expression of plasma-type platelet-activating factor acetyl...
23042518 - Barrier protective effects of rosmarinic acid on hmgb1-induced inflammatory responses i...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Redox report : communications in free radical research     Volume:  6     ISSN:  1351-0002     ISO Abbreviation:  Redox Rep.     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-28     Completed Date:  2002-02-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9511366     Medline TA:  Redox Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / drug therapy
Antineoplastic Agents / pharmacology*,  therapeutic use
Antioxidants / pharmacology*,  therapeutic use
Apoptosis / drug effects*
Cell Cycle / drug effects
Colonic Neoplasms / drug therapy
Drug Screening Assays, Antitumor
Free Radical Scavengers / pharmacology,  therapeutic use
Free Radicals
Gene Expression Regulation / drug effects
Intestinal Mucosa / drug effects
Intracellular Membranes / drug effects
Lysosomes / drug effects
Macrophages / drug effects
Mice, Nude
Mitochondria / drug effects
Molecular Structure
Neoplastic Stem Cells / drug effects
Protein Kinase C / physiology
Reactive Oxygen Species
Signal Transduction / drug effects
Stem Cells / drug effects
Tumor Cells, Cultured / drug effects
Vitamin E / analogs & derivatives*,  pharmacology*,  therapeutic use
Xenograft Model Antitumor Assays
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antioxidants; 0/Free Radical Scavengers; 0/Free Radicals; 0/Reactive Oxygen Species; 1406-18-4/Vitamin E; 1406-66-2/Tocopherols; EC Kinase C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The role of cerebral oedema in the pathogenesis of cerebral malaria.
Next Document:  Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro.