| Vitamin E Ameliorates Iodine-induced Cytotoxicity in Thyroid. | |
| | |
MedLine Citation:
|
PMID: 21406454 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Acute and excessive iodine supplementation leads to iodine-induced thyroid cytotoxicity. Excessive oxidative stress has been suggested to be one of the underlying mechanisms in the development of thyroid cytotoxicity. The aim of this study was to investigate whether Vitamin E (VE), an important antioxidant, may could ameliorate iodine-induced thyroid cytotoxicity. A goiter was induced in rats by feeding a low-iodine diet for 12 weeks. Involution of hyperplasia was obtained by administering a 2-fold physiological dose of iodine in feeding water with/without supplementation of 25, 50, or 100-fold physiological dose of VE in the low-iodine diet for 4 weeks. In iodine supplemented rats, thyroid epithelial cell ultrastructure injuries remained and were more severe. Relative weights of iodine-induced involuting glands were significantly reduced compared to the goiter, but still higher than control. Immunohistochemistry indicated that the expression of 4-hydroxynonenal (4-HNE), 8-hydroxyguanine (8-OHdG), peroxiredoxin 5 (PRDX5), and CD68 in thyroid increased (P<0.01), whereas TrxR-1 decreased (P<0.01). Vitamin E (VE) supplementation attenuated thyroid cytotoxicity induced by iodine. A 50-fold VE dose was optimal in attenuating 2-fold iodine-induced thyroid cytotoxicity. However, VE supplementation did not reduce the weight or relative weight of the iodine-induced involuting gland. These results show that excess iodine leads to thyroid damage and VE supplementation can partly ameliorate iodine-induced thyroid cytotoxicity. |
| | |
Authors:
|
Jiashu Yu; Zhongyan Shan; Wei Chong; Jinyuan Mao; Yuxiu Geng; Caixia Zhang; Qian Xing; Weiwei Wang; Ningna Li; Chenling Fan; Hong Wang; Hongmei Zhang; Weiping Teng |
Related Documents
:
|
15621064 - Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat met... 18814804 - Effects of oral fat perception by modified sham feeding on energy expenditure, hormones... 20067964 - Effect of pioglitazone on energy intake and ghrelin in diabetic patients. 20388134 - Can bioactive foods affect obesity? 9885774 - Cholesterol ester transfer protein: a molecule with three faces? 20723704 - Increasing milk solids production across lactation through genetic selection and intens... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
|
Title: The Journal of endocrinology Volume: - ISSN: 1479-6805 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
J Yu, The Endocrine Institute of China Medical University, Shenyang, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Procalcitonin in detecting neonatal nosocomial sepsis.
Next Document: How large are the productivity losses in contemporary patients with RA, and how soon in relation to ...