Document Detail


Vitamin deficiencies in humans: can plant science help?
MedLine Citation:
PMID:  22374394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The term vitamin describes a small group of organic compounds that are absolutely required in the human diet. Although for the most part, dependency criteria are met in developed countries through balanced diets, this is not the case for the five billion people in developing countries who depend predominantly on a single staple crop for survival. Thus, providing a more balanced vitamin intake from high-quality food remains one of the grandest challenges for global human nutrition in the coming decade(s). Here, we describe the known importance of vitamins in human health and current knowledge on their metabolism in plants. Deficits in developing countries are a combined consequence of a paucity of specific vitamins in major food staple crops, losses during crop processing, and/or overreliance on a single species as a primary food source. We discuss the role that plant science can play in addressing this problem and review successful engineering of vitamin pathways. We conclude that while considerable advances have been made in understanding vitamin metabolic pathways in plants, more cross-disciplinary approaches must be adopted to provide adequate levels of all vitamins in the major staple crops to eradicate vitamin deficiencies from the global population.
Authors:
Teresa B Fitzpatrick; Gilles J C Basset; Patrick Borel; Fernando Carrari; Dean DellaPenna; Paul D Fraser; Hanjo Hellmann; Sonia Osorio; Christophe Rothan; Victoriano Valpuesta; Catherine Caris-Veyrat; Alisdair R Fernie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-02-28
Journal Detail:
Title:  The Plant cell     Volume:  24     ISSN:  1532-298X     ISO Abbreviation:  Plant Cell     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-03-28     Completed Date:  2012-08-08     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9208688     Medline TA:  Plant Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-414     Citation Subset:  IM    
Affiliation:
Department of Botany and Plant Biology, University of Geneva, 1211 Geneva, Switzerland. theresa.fitzpatrick@unige.ch
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MeSH Terms
Descriptor/Qualifier:
Avitaminosis / prevention & control*
Breeding
Chromosome Mapping
Crops, Agricultural / metabolism*
Developing Countries
Food, Fortified
Genetic Variation
Humans
Plants / genetics,  metabolism*
Plants, Genetically Modified / genetics,  metabolism
Vitamins / biosynthesis*
Chemical
Reg. No./Substance:
0/Vitamins
Comments/Corrections

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